5-bromonaphthalen-2-ol

Base Information

• Chemical Name: 5-bromonaphthalen-2-ol
• CAS No.: 116632-05-4
• Molecular Formula: C10H7BrO
• Molecular Weight: 223.069
• Mol file: 116632-05-4.mol

Synonyms:5-BroMo-2-naphthalenol;5-Bromonaphthalen-2-ol

Chemical Property of 5-bromonaphthalen-2-ol

Chemical Property:

• Melting Point: 110-111 °C
• Boiling Point: 353.8±15.0 °C(Predicted)
• PKA: 9.10±0.40(Predicted)
• PSA: 20.23000
• Density: 1.614±0.06 g/cm3(Predicted)
• LogP: 3.30790

Purity/Quality:

95% ^*data from raw suppliers

5-Bromo-2-naphthalenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-naphthalenol, can be used in the synthesis of substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. It is also used in the preparation of Fluoranthenes (F461990).

Technology Process of 5-bromonaphthalen-2-ol

There total 11 articles about 5-bromonaphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-bromo-6-methoxynaphthalene (83710-62-7) → 5-bromonaphthalen-2-ol (116632-05-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1002/anie.201814381

Reference yield: 63.0%

5-bromo-2-hydroxynaphthalene-1-sulfonic acid → 5-bromonaphthalen-2-ol (116632-05-4)

Guidance literature:

With sulfuric acid; In water; for 0.333333h; Reflux;

DOI:10.1002/cmdc.201800158

Reference yield:

5-amino-2-hydroxynaphthalene-1-sulfonic acid → 5-bromonaphthalen-2-ol (116632-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; sulfuric acid; sodium hydroxide / water / 0 - 5 °C

1.2: 1 h / 70 °C

1.3: 20 °C

2.1: sulfuric acid / water / 0.33 h / Reflux

With sulfuric acid; sodium hydroxide; sodium nitrite; In water;

DOI:10.1002/cmdc.201800158

upstream raw materials:

1,6-dibromonaphthalene

7-bromo-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one

1,6-dibromonaphthalen-2-amine

5-amino-2-naphthol

Downstream raw materials:

1-bromo-6-methoxynaphthalene

4-(5-(4-(t-butyl)phenyl)naphthalen-2-yl)-N,N-dimethylaniline

C₂₉H₃₂N⁽¹⁺⁾

C₃₁H₂₇N

Refernces

• 1、 -. "TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND". . . Retrieved 2021/07/17.
• 2、 -. "PYRAZOLE-CONTAINING MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS". . . Retrieved 2019/10/04.