Hydroxyzine Hcl

Base Information

• Chemical Name: Hydroxyzine Hcl
• CAS No.: 2192-20-3
• Deprecated CAS: 39081-05-5
• Molecular Formula: C21H27ClN2O2^.2(HCl)
• Molecular Weight: 447.832
• Hs Code.: 29335990
• European Community (EC) Number: 214-989-3
• UNII: CA67JF5Q4W
• DSSTox Substance ID: DTXSID5047530
• Wikidata: Q27275377
• NCI Thesaurus Code: C47559
• RXCUI: 154987
• Pharos Ligand ID: SG8F7RTDBHGV
• ChEMBL ID: CHEMBL1201007
• Mol file: 2192-20-3.mol

Synonyms:2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol;Atarax;Durrax;Hydroxyzine;Hydroxyzine Dihydrochloride;Hydroxyzine Hydrochloride;Hydroxyzine Pamoate;Orgatrax;Pamoate, Hydroxyzine;Vistaril

Chemical Property of Hydroxyzine Hcl

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 8.78E-11mmHg at 25°C
• Melting Point: 190-192 °C
• Boiling Point: 499.2 °C at 760 mmHg
• Flash Point: 255.7 °C
• PSA: 35.94000
• Density: 1.182 g/cm3
• LogP: 4.53570
• Storage Temp.: Refrigerator
• Solubility.: H2O: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 410.1527835
• Heavy Atom Count: 27
• Complexity: 376

Purity/Quality:

Above 99% ^*data from raw suppliers

Hydroxyzine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl
• Recent ClinicalTrials: Preoperative Use of Alprazolam and Hydroxyzine in Anxiety
• Uses: H1 receptor antagonist. Anxiolytic. Antihistaminic. Antihistaminic;H1 antogonist Anti histamines Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
• Therapeutic Function: Tranquilizer

Technology Process of Hydroxyzine Hcl

There total 1 articles about Hydroxyzine Hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-chlorobenzhydryl)piperazine (303-26-4) + 2-(2-Chloroethoxy)ethanol (628-89-7) → hydroxyzine dihydrochloride (2192-20-3,163837-37-4)

Guidance literature:

N-(4-chlorobenzhydryl)piperazine; With tetrabutylammomium bromide; potassium carbonate; In water; at 25 ℃;

2-(2-Chloroethoxy)ethanol; In water; at 80 ℃; for 5h;

With hydrogenchloride;

Reference yield: 90.0%

1-bromo-2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethane (854601-80-2,92450-98-1) + hydroxyzine dihydrochloride (2192-20-3,163837-37-4) → mPEG5-hydroxyzine (854601-76-6)

Guidance literature:

hydroxyzine dihydrochloride; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;

1-bromo-2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethane; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 60.0%

jones reagent + hydroxyzine dihydrochloride (2192-20-3,163837-37-4) + pyrographite (7440-44-0) → cetirizine (83881-51-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sulfuric acid; In water; isopropyl alcohol; acetone;

upstream raw materials:

N-(4-chlorobenzhydryl)piperazine

2-(2-Chloroethoxy)ethanol

Downstream raw materials:

cetirizine

mPEG₅-hydroxyzine

Refernces