1-(2-Methylphenyl)-3-phenylurea

Base Information

• Chemical Name: 1-(2-Methylphenyl)-3-phenylurea
• CAS No.: 13140-49-3
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Hs Code.: 2924299090
• Mol file: 13140-49-3.mol

Synonyms:1-(2-Methylphenyl)-3-phenylurea;1-Phenyl-3-(2-methylphenyl)urea;2-Methylcarbanilide;N-(2-Methylphenyl)-N'-phenylurea;1-PHENYL-3-(O-TOLYL)UREA

Chemical Property of 1-(2-Methylphenyl)-3-phenylurea

Chemical Property:

• PSA: 44.62000
• LogP: 3.72560

Purity/Quality:

1-PHENYL-3-(O-TOLYL)UREA Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Methylphenyl)-3-phenylurea

There total 36 articles about 1-(2-Methylphenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) + o-toluidine (95-53-4) → N-(2-methylphenyl)-N'-phenylurea (13140-49-3)

Guidance literature:

With sodium acetate; In methanol; at 60 ℃; for 2h;

Reference yield: 95.5%

phenyl isocyanate (103-71-9) + o-toluidine (95-53-4) → N-(2-methylphenyl)-N'-phenylurea (13140-49-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol0508025 DOI:10.1039/b507202f

Reference yield: 95.0%

2-methylphenyl bromide (95-46-5) + phenyl carbamate (64-10-8) → N-(2-methylphenyl)-N'-phenylurea (13140-49-3)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(bis(3,5-bis(trifluoromethyl)phenyl)phosphine); In 1,4-dioxane; at 100 ℃; for 1h;

DOI:10.1016/S0040-4039(03)01051-7

upstream raw materials:

ethanol

N-phenyl-N'-(o-tolyl)carbodiimide

1-phenyl 3-o-tolylthiocarbamide

phenyl isocyanate

Downstream raw materials:

N,N'-bis(2-methylphenyl)urea

orange OT

1-benzyl-1-(2-methylphenyl)-3-phenylurea

1-phenyl 3-o-tolylthiocarbamide

Refernces

• 1、 Zhu, Xiancui,Xu, Mengchen,Sun, Jinrong,Guo, Dianjun,Zhang, Yiwei,Zhou, Shuangliu,Wang, Shaowu. "Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions". . p. 5213 - 5218. Retrieved 2021/10/19.
• 2、 Wang, Liang,Wang, Hao,Wang, Yaoyao,Shen, Minggui,Li, Shubai. "Photocatalyzed synthesis of unsymmetrical ureas via the oxidative decarboxylation of oxamic acids with PANI-g-C3N4-TiO2 composite under visible light". supporting information. . Retrieved 2020/04/28.