2-(Benzyloxy)pyridin-4-aMine

Base Information

• Chemical Name: 2-(Benzyloxy)pyridin-4-aMine
• CAS No.: 1214900-01-2
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Mol file: 1214900-01-2.mol

Synonyms:2-(Benzyloxy)pyridin-4-aMine;2-(PhenylMethoxy)-4-pyridinaMine;4-AMino-2-benzyloxypyridine

Chemical Property of 2-(Benzyloxy)pyridin-4-aMine

Chemical Property:

• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2-benzyloxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Benzyloxy)pyridin-4-aMine is used in preparation of nicotinamide derivatives as Syk inhibitors.

Technology Process of 2-(Benzyloxy)pyridin-4-aMine

There total 1 articles about 2-(Benzyloxy)pyridin-4-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(benzyloxy)pyridin-4-amine (1214900-01-2)

Guidance literature:

With sodium hydroxide; at 150 ℃; for 5h; Sealed tube;

Reference yield: 43.0%

2-(benzyloxy)pyridin-4-amine (1214900-01-2) + 3-fluoro-5-[2-methoxy-4-(trifluoromethoxy)phenoxy]-2- (trifluoromethyl)pyridine-4-carboxylic acid → C27H18F7N3O5

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

2-(benzyloxy)pyridin-4-amine (1214900-01-2) → 4-amino-3-bromo-2(1H)-pyridinone (107842-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) bromide / acetonitrile / 168 h / 20 °C

2: hydrogenchloride / methanol / Reflux

With hydrogenchloride; copper(ll) bromide; In methanol; acetonitrile;

DOI:10.1055/s-0035-1560469

Downstream raw materials:

4-amino-3-bromo-2(1H)-pyridinone

Refernces