ETHYL 4-METHOXY-2,6-DIMETHYLBENZOATE

Base Information

• Chemical Name: ETHYL 4-METHOXY-2,6-DIMETHYLBENZOATE
• CAS No.: 412949-76-9
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol file: 412949-76-9.mol

Synonyms:ETHYL 4-METHOXY-2,6-DIMETHYLBENZOATE

Chemical Property of ETHYL 4-METHOXY-2,6-DIMETHYLBENZOATE

Chemical Property:

• PSA: 35.53000
• LogP: 2.48870

Purity/Quality:

98% ^*data from raw suppliers

4-Methoxy-2,6-dimethyl-benzoicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-METHOXY-2,6-DIMETHYLBENZOATE

There total 1 articles about ETHYL 4-METHOXY-2,6-DIMETHYLBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2,6-dimethyl-4-methoxycyclohexa-1,3-dienecarboxylate (100667-93-4) → 3,5-dimethylmethoxybenzene (874-63-5) + ethyl 4-methoxy-2,6-dimethylbenzoate (412949-76-9)

Guidance literature:

palladium on activated charcoal; In diethylene glycol dimethyl ether; at 220 ℃; for 14h;

DOI:10.1016/S0968-0896(01)00273-5

Reference yield: 30.0%

ethyl 4-methoxy-2,6-dimethylbenzoate (412949-76-9) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 2-ethoxycarbonylmethyl-4-methoxy-6-methylbenzoate (412949-78-1) + ethyl 2-diethoxycarbonylmethyl-4-methoxy-6-methylbenzoate

Guidance literature:

ethyl 4-methoxy-2,6-dimethylbenzoate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

Diethyl carbonate; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1016/S0968-0896(01)00273-5

Reference yield:

ethyl 4-methoxy-2,6-dimethylbenzoate (412949-76-9) → 2-carboxymethyl-4-methoxy-6-methylbenzoic acid (412949-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 0.08 h / -78 °C

1.2: 30 percent / tetrahydrofuran; hexane / 1 h / -78 °C

2.1: 82 percent / NaOH / ethanol; H₂O / 16 h / Heating

With sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; water;

DOI:10.1016/S0968-0896(01)00273-5

upstream raw materials:

ethyl 2,6-dimethyl-4-methoxycyclohexa-1,3-dienecarboxylate

Downstream raw materials:

ethyl 2-ethoxycarbonylmethyl-4-methoxy-6-methylbenzoate

2-carboxymethyl-4-methoxy-6-methylbenzoic acid

Refernces