6H-chromeno[4,3-b]quinoline

Base Information

• Chemical Name: 6H-chromeno[4,3-b]quinoline
• CAS No.: 225-55-8
• Molecular Formula: C16H11 N O
• Molecular Weight: 233.269
• Hs Code.: 2934999090
• Mol file: 225-55-8.mol

Synonyms:6H-5-Oxa-12-azabenz[a]anthracene;6H-Chromeno[4,3-b]quinoline

Chemical Property of 6H-chromeno[4,3-b]quinoline

Chemical Property:

• Vapor Pressure: 8.66E-08mmHg at 25°C
• Melting Point: 121.5 °C
• Boiling Point: 447.8°Cat760mmHg
• PKA: 4.14±0.20(Predicted)
• Flash Point: 160.8°C
• PSA: 22.12000
• Density: 1.264g/cm³
• LogP: 3.79420

Purity/Quality:

6H-[1]BENZOPYRANO[4,3-B]QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6H-chromeno[4,3-b]quinoline

There total 20 articles about 6H-chromeno[4,3-b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

o-propargyloxybenzaldehyde (29978-83-4) + aniline (62-53-3) → 6H-<1> benzopyranno <4,3-b> quinoleine (225-55-8)

Guidance literature:

With copper(l) iodide; lanthanum(lll) triflate; In acetonitrile; for 4h; Reflux;

DOI:10.1055/s-0029-1219364

Reference yield: 83.0%

C16H12ClNO (105271-79-2) → 6H-<1> benzopyranno <4,3-b> quinoleine (225-55-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1016/j.tet.2017.03.043

Reference yield: 72.0%

propargyloxy-2 salicylanilide (66362-36-5) → 6H-<1> benzopyranno <4,3-b> quinoleine (225-55-8)

Guidance literature:

With trichlorophosphate; In toluene; for 48h; Heating;

DOI:10.1016/S0040-4039(00)81930-9

upstream raw materials:

2,3-dihydro-4H-1-benzopyran-4-one

o-aminobenzaldehyde

phenyl-[3-(phenylimino-methyl)-2H-chromen-4-yl]-amine; hydrochloride

propargyloxy-2 salicylanilide

Refernces

• 1、 Shiri, Morteza,Fathollahi-Lahroud, Mina,Yasaei, Zahra. "A novel strategy for the synthesis of 6H-chromeno [4, 3-b] quinoline by intramolecular Heck cyclization". . p. 2501 - 2503. Retrieved 2017.
• 2、 Rahimzadeh, Golnaz,Soheilizad, Mehdi,Kianmehr, Ebrahim,Larijani, Bagher,Mahdavic, Mohammad. "Copper-catalyzed intramolecular domino synthesis of 6H-chromeno[4,3-b]quinolines in green condition". . p. 20 - 28. Retrieved 2018/06/27.