4-(4-Methylphenoxy)benzylamine hydrochloride

Base Information

• Chemical Name: 4-(4-Methylphenoxy)benzylamine hydrochloride
• CAS No.: 262862-66-8
• Molecular Formula: C14H16ClNO
• Molecular Weight: 249.74
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID80590035
• Mol file: 262862-66-8.mol

Synonyms:262862-66-8;4-(4-Methylphenoxy)benzylamine hydrochloride;4-(4-METHYLPHENOXY)BENZYLAMINE HCL;(4-(p-tolyloxy)phenyl)methanamine hydrochloride;4-(4-Methylphenoxy)benzylamine, HCl;[4-(4-Methylphenoxy)Phenyl]Methanamine Hydrochloride;[4-(4-methylphenoxy)phenyl]methanamine;hydrochloride;[4-(4-Methylphenoxy)phenyl]methylamine hydrochloride;[4-(4-methylphenoxy)phenyl]methanamine,hydrochloride;SCHEMBL6160193;DTXSID80590035;AR1874;MFCD02089411;(4-(p-tolyloxy)phenyl)methanamine hcl;AKOS022182187;AS-45227;4-(4-Methylphenoxy)benzylaminehydrochloride;CS-0073025;A919603;SR-01000368630;SR-01000368630-1;F9994-0681;1-[4-(4-METHYLPHENOXY)PHENYL]METHANAMINE HYDROCHLORIDE;1-[4-(4-Methylphenoxy)phenyl]methanamine--hydrogen chloride (1/1)

Chemical Property of 4-(4-Methylphenoxy)benzylamine hydrochloride

Chemical Property:

• PSA: 35.25000
• LogP: 4.74830
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 249.0920418
• Heavy Atom Count: 17
• Complexity: 191

Purity/Quality:

98% ^*data from raw suppliers

[4-(4-Methylphenoxy)phenyl]methylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)OC2=CC=C(C=C2)CN.Cl

Technology Process of 4-(4-Methylphenoxy)benzylamine hydrochloride

There total 4 articles about 4-(4-Methylphenoxy)benzylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4‐(p‐tolyloxy)phenyl)methanamine (129560-03-8) → 4-(4-methylphenoxy)benzylamine hydrochloride (262862-66-8)

Guidance literature:

With hydrogenchloride; In methanol; toluene; Reagent/catalyst; Large scale;

Reference yield:

p-cresol (106-44-5) → 4-(4-methylphenoxy)benzylamine hydrochloride (262862-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 1.5 h / Reflux; Large scale

1.2: 2 h / 155 °C / Large scale

2.1: ammonia; hydrogen / methanol / 3 h / 55 °C / 26252.6 Torr / Inert atmosphere; Large scale

3.1: hydrogenchloride / methanol; toluene / Large scale

With hydrogenchloride; ammonia; hydrogen; sodium methylate; In methanol; toluene;

Reference yield:

4-Cyanochlorobenzene (623-03-0) → 4-(4-methylphenoxy)benzylamine hydrochloride (262862-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 1.5 h / Reflux; Large scale

1.2: 2 h / 155 °C / Large scale

2.1: ammonia; hydrogen / methanol / 3 h / 55 °C / 26252.6 Torr / Inert atmosphere; Large scale

3.1: hydrogenchloride / methanol; toluene / Large scale

With hydrogenchloride; ammonia; hydrogen; sodium methylate; In methanol; toluene;

upstream raw materials:

p-cresol

4-Cyanochlorobenzene

4-(4'-methylphenoxy)benzonitrile

(4‐(p‐tolyloxy)phenyl)methanamine

Downstream raw materials:

N-[4-(4-methylphenoxy)benzyl]-4-chloro-3-ethyl-1-methyl-5-pyrazolecarboxamide

(S)-3-acetoxy-1-[4-(4'-methylphenoxy)benzyl]pyrrolidine-2,5-dione

Refernces