5α-Androstan-11-one

Base Information

• Chemical Name: 5α-Androstan-11-one
• CAS No.: 1755-32-4
• Molecular Weight: 274.4409
• Mol file: 1755-32-4.mol

Synonyms:

Chemical Property of 5α-Androstan-11-one

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5α-Androstan-11-one

There total 18 articles about 5α-Androstan-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5αH-androstan-3,11,17-trione (1482-70-8) → 5αH-androstan-11-one (1755-32-4)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In diethylene glycol;

DOI:10.1021/ja00310a046

Reference yield:

Cortisone (53-06-5) → 5αH-androstan-11-one (1755-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / side-chain oxidation

2: 1.) lithium; 2.) Jones reagent / 1.) dioxane, liq. ammonia, 30 min; 2.) acetone, 0 deg C, 10 min

3: 70 percent / hydrazine hydrate, potassium hydroxide / bis-(2-hydroxy-ethyl) ether

With potassium hydroxide; jones reagent; lithium; hydrazine hydrate; In diethylene glycol;

DOI:10.1021/ja00310a046

Reference yield:

androst-4-en-3,11,17-trione (382-45-6) → 5αH-androstan-11-one (1755-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) lithium; 2.) Jones reagent / 1.) dioxane, liq. ammonia, 30 min; 2.) acetone, 0 deg C, 10 min

2: 70 percent / hydrazine hydrate, potassium hydroxide / bis-(2-hydroxy-ethyl) ether

With potassium hydroxide; jones reagent; lithium; hydrazine hydrate; In diethylene glycol;

DOI:10.1021/ja00310a046

upstream raw materials:

5α-androstan-11β-ol

5α-androstane-3,11,17-trione

5αH-androstan-3,11,17-trione

C₂₃H₃₄OS₄

Downstream raw materials:

5α-Androstan-11α-ol

5α-androstan-11β-ol

5α-Androstan-6,11-dion

5α-Androstan-1,6-dion

Refernces

• 1、 Patterson,Djerassi,Yuh,Allinger. "Factors governing the relative stabilities of the C/D cis and trans ring junctures in delta8-11-keto steroids.". . p. 2365 - 2370,2366, 2368. Retrieved 2007/10/11.