4-Chloro-6-Methylnicotinic acid

Base Information

• Chemical Name: 4-Chloro-6-Methylnicotinic acid
• CAS No.: 1060805-95-9
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.58104
• Hs Code.: 2933399090
• Mol file: 1060805-95-9.mol

Synonyms:4-Chloro-6-methyl-3-pyridinecarboxylic acid

Chemical Property of 4-Chloro-6-Methylnicotinic acid

Chemical Property:

• Melting Point: 162-164℃
• Boiling Point: 312.3±37.0 °C(Predicted)
• PKA: 1.03±0.25(Predicted)
• PSA: 50.19000
• Density: 1.390
• LogP: 1.74160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-6-methylnicotinicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-6-Methylnicotinic acid

There total 1 articles about 4-Chloro-6-Methylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-hydroxy-6-methylnicotinic acid (67367-33-3) → 4-chloro-6-methylnicotinic acid (1060805-95-9)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 14h; Inert atmosphere;

DOI:10.1039/b924679g

Reference yield: 91.0%

methanol (67-56-1) + 4-chloro-6-methylnicotinic acid (1060805-95-9) → methyl 4-chloro-6-methylpyridine-3-carboxylate (886372-05-0)

Guidance literature:

4-chloro-6-methylnicotinic acid; With trichlorophosphate; for 2h; Reflux;

methanol; at 0 - 20 ℃;

DOI:10.1002/cmdc.201300144

Reference yield: 30.0%

4-chloro-6-methylnicotinic acid (1060805-95-9) + phenol (108-95-2,27073-41-2) → 4-phenoxy-6-methylnicotinic acid (1227180-59-7)

Guidance literature:

With sodium methylate; In methanol; at 65 ℃; for 1h; Inert atmosphere;

DOI:10.1039/b924679g

upstream raw materials:

4-hydroxy-6-methylnicotinic acid

Downstream raw materials:

4-phenoxy-6-methylnicotinic acid

methyl 4-chloro-6-methylpyridine-3-carboxylate

4-phenyl-6-methylnicotinic acid methyl ester

4-thiophenoxy-6-methylnicotinic acid

Refernces

• 1、 -. "PROLYL HYDROXYLASE INHIBITORS". Page/Page column 13-14. . Retrieved 2010/07/10.