Rosuvastatin IMpurity SodiuM Salt (5-Oxo Rosuvastatin SodiuM Salt)

Base Information

• Chemical Name: Rosuvastatin IMpurity SodiuM Salt (5-Oxo Rosuvastatin SodiuM Salt)
• CAS No.: 1422619-13-3
• Molecular Formula: C22H26FN3O6S
• Molecular Weight: 479.52
• Mol file: 1422619-13-3.mol

Synonyms:Rosuvastatin IMpurity SodiuM Salt (5-Oxo Rosuvastatin SodiuM Salt);(3r,6e)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3-hydroxy-5-oxo-6-heptenoic acid;(3R,6E)-7-[4-(4-uorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]- 3-hydroxy-5-oxohept-6-enoic acid;Rosuvastatin calcium EP Impurity C;3-Hydroxy-5-keto Rosuvastatin;Rosuvastatin (R700500) impurity

Chemical Property of Rosuvastatin IMpurity SodiuM Salt (5-Oxo Rosuvastatin SodiuM Salt)

Chemical Property:

• Boiling Point: 731.0±70.0 °C(Predicted)
• PKA: 4.17±0.10(Predicted)
• PSA: 146.14000
• Density: 1.365±0.06 g/cm3(Predicted)
• LogP: 3.69070

Purity/Quality:

99% ^*data from raw suppliers

5-OxoRosuvastatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Oxo Rosuvastatin (Rosuvastatin EP Impurity C (Calcium Salt)) is a Rosuvastatin (R700500) impurity.

Technology Process of Rosuvastatin IMpurity SodiuM Salt (5-Oxo Rosuvastatin SodiuM Salt)

There total 9 articles about Rosuvastatin IMpurity SodiuM Salt (5-Oxo Rosuvastatin SodiuM Salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate (147118-39-6) → 7-[4-(4-fluorophenyl)-6-isopropyl-2(N-methyl-N-methanesulfonamido)pyrimidin-5-yl]-(3R)-3-hydroxy-5-carbonyl-6-(E)-heptenoic acid (1422619-13-3)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 10 - 15 ℃; for 0.5h;

Reference yield: 96.0%

(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester → 7-[4-(4-fluorophenyl)-6-isopropyl-2(N-methyl-N-methanesulfonamido)pyrimidin-5-yl]-(3R)-3-hydroxy-5-carbonyl-6-(E)-heptenoic acid (1422619-13-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 5 ℃; for 2h; Temperature;

Reference yield:

crestor → 7-[4-(4-fluorophenyl)-6-isopropyl-2(N-methyl-N-methanesulfonamido)pyrimidin-5-yl]-(3R)-3-hydroxy-5-carbonyl-6-(E)-heptenoic acid (1422619-13-3)

Guidance literature:

With dihydrogen peroxide; In water; at 50 ℃; for 168h; chemoselective reaction; Sealed tube;

DOI:10.1016/j.xphs.2018.10.059

upstream raw materials:

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Refernces

• 1、 -. "A rosuvastatin calcium impurity preparation method". . . Retrieved 2017/08/26.