ML-323

Base Information

• Chemical Name: ML-323
• CAS No.: 1572414-83-5
• Molecular Formula: C23H24N6
• Molecular Weight: 384.47686
• Hs Code.: 29299090
• Mol file: 1572414-83-5.mol

Synonyms:ML-323;5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine;4-Pyrimidinamine, 5-methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-;5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine ML323;ML323, >=98%

Chemical Property of ML-323

Chemical Property:

• Boiling Point: 515.4±60.0 °C(Predicted)
• PKA: 5.37±0.10(Predicted)
• PSA: 68.52000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 4.84120
• Storage Temp.: -20°C
• Solubility.: Soluble in DMSO (up to 40 mg/ml), or in Ethanol (up to 20 mg/ml)

Purity/Quality:

98%Min ^*data from raw suppliers

ML323 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: ML323 (1571424-83-5) is a potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nM in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 μM.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2? ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3
• Uses: ML323 is a highly potent and selective USP1-UAF1 inhibitor.