5-METHYLNICOTINAMIDE

Base Information

• Chemical Name: 5-METHYLNICOTINAMIDE
• CAS No.: 70-57-5
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• Mol file: 70-57-5.mol

Synonyms:Nicotinamide,5-methyl- (7CI,8CI);5-Methyl-3-pyridinecarboxamide;5-Methylnicotinamide;NSC87668;

Chemical Property of 5-METHYLNICOTINAMIDE

Chemical Property:

• Vapor Pressure: 0.00213mmHg at 25°C
• Melting Point: 166-168°C
• Refractive Index: 1.561
• Boiling Point: 290 °C at 760 mmHg
• Flash Point: 129.2 °C
• PSA: 55.98000
• Density: 1.157g/cm³
• LogP: 1.18920
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%, ^*data from raw suppliers

5-Methylnicotinamide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Methylnicotinamide can be used to treat necrotizing enterocolitis.

Technology Process of 5-METHYLNICOTINAMIDE

There total 6 articles about 5-METHYLNICOTINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,5-Lutidine (591-22-0) → 5-methylpyridinylcarboxamide (70-57-5)

Guidance literature:

With manganese(IV) oxide; oxygen; urea; at 150 ℃; for 4h; under 3800.26 Torr; Autoclave;

DOI:10.1002/anie.201203098

Reference yield: 74.0%

ethyl 5-methyl-3-pyridinecarboxylate (20826-02-2) → 5-methylpyridinylcarboxamide (70-57-5)

Guidance literature:

With ammonium hydroxide; for 24h; Ambient temperature;

Reference yield: 73.0%

5-methyl-nicotinic acid chloride (884494-95-5) → 5-methylpyridinylcarboxamide (70-57-5)

Guidance literature:

With ammonia; In 1,2-dichloro-ethane; at -30 - 20 ℃; Heating / reflux;

upstream raw materials:

5-methyl-nicotinic acid chloride

ethyl 5-methyl-3-pyridinecarboxylate

3,5-Lutidine

5-methylnicotinic acid

Downstream raw materials:

5-methylpyridin-3-amine

C₂₆H₂₃Cl₂N₂O₆⁽¹⁺⁾

(2-Amino-3,5-difluoro-phenyl)-(5-fluoro-pyridin-3-yl)-methanone

(5-fluoropyridin-3-yl)methanol

Refernces

• 1、 Wang, Ye,Yamaguchi, Kazuya,Mizuno, Noritaka. "Manganese oxide promoted liquid-phase aerobic oxidative amidation of methylarenes to monoamides using ammonia surrogates". supporting information; experimental part. p. 7250 - 7253. Retrieved 2012/08/28.
• 2、 -. "A process for the preparation of 4-[2-(aryl or heterocyclo)-1H-imidazol-1-yl]benzenesulfonamides". Page 72. . Retrieved 2010/01/31.