δ-2-CefodiziMe (2 :1 Mixture)

Base Information

• Chemical Name: δ-2-CefodiziMe (2 :1 Mixture)
• CAS No.: 120533-30-4
• Molecular Formula: C20H20N6O7S4
• Molecular Weight: 584.679
• Mol file: 120533-30-4.mol

Synonyms:δ-2-CefodiziMe (2 :1 Mixture);δ-2-Cefodizime

Chemical Property of δ-2-CefodiziMe (2 :1 Mixture)

Chemical Property:

• PKA: 2.29±0.60(Predicted)
• PSA: 304.48000
• Density: 1.86±0.1 g/cm3(Predicted)
• LogP: 1.90710
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Δ-2-Cefodizime(~2:1C242885toC242865) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: δ-2-Cefodizime is a derivative of Cefodizime, a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections. δ-2-Cefodizime is a third generation of cephalosporin with a broad spectrum of antibacterial activity. It is also a derivative of Cefodizime which maybe useful in the treatment of otitis media, sinusitis, gynaecological infections, and for the prophylaxis or treatment of surgical infections.

Technology Process of δ-2-CefodiziMe (2 :1 Mixture)

There total 3 articles about δ-2-CefodiziMe (2 :1 Mixture) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Kenicef (86329-79-5) → 2-<<(2-amino-4-thiazolyl)((Z)-methoxyimino)acetyl>amino>acetoaldehyde (104301-63-5) + 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole (34272-64-5) + (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-(5-carboxymethyl-4-methyl-thiazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid (120533-30-4) + cefodizime (69739-16-8,120533-29-1)

Guidance literature:

With sodium hydroxide; at 18 ℃; for 1h; Yield given;

DOI:10.1248/cpb.37.513

Reference yield:

Kenicef (86329-79-5) → 2-<<(2-amino-4-thiazolyl)((Z)-methoxyimino)acetyl>amino>acetoaldehyde (104301-63-5) + 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole (34272-64-5) + (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-(5-carboxymethyl-4-methyl-thiazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid (120533-30-4) + cefodizime (69739-16-8,120533-29-1)

Guidance literature:

With sodium hydroxide; at 18 ℃; for 1h; degradation in variuos conditions;

DOI:10.1248/cpb.37.513

Reference yield:

Kenicef (86329-79-5) → (-)-(6R,7R)-7-<(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido>-3-<<<5-(carboxymethyl)-4-methyl-2-thiazolyl>thio>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-3-ene-2-carboxylic acid (120533-30-4,123238-78-8)

Guidance literature:

With water; at 100 ℃; for 2h; Yield given;

DOI:10.1248/cpb.37.367

upstream raw materials:

Kenicef

Refernces

• 1、 Marunaka,Matsushima,Minami,Azuma,Yoshida,Umeno. "Acidic degradation of cefodizime (THR-221) and structural elucidation of the products. I". . p. 367 - 372. Retrieved 2007/10/02.