4-Phenoxy-2-methoxyphenylboronic acid pinacol ester

Base Information

• Chemical Name: 4-Phenoxy-2-methoxyphenylboronic acid pinacol ester
• CAS No.: 1196395-39-7
• Molecular Formula: C19H23BO4
• Molecular Weight: 326.2
• Mol file: 1196395-39-7.mol

Synonyms:4-Phenoxy-2-methoxyphenylboronic acid pinacol ester

Chemical Property of 4-Phenoxy-2-methoxyphenylboronic acid pinacol ester

Chemical Property:

• PSA: 36.92000
• LogP: 3.78670

Purity/Quality:

98%min ^*data from raw suppliers

4-Phenoxy-2-methoxyphenylboronic acid pinacol ester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Phenoxy-2-methoxyphenylboronic acid pinacol ester

There total 4 articles about 4-Phenoxy-2-methoxyphenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-bromo-2-methoxy-4-phenoxy-benzene + bis(pinacol)diborane (73183-34-3) → 2-(2-methoxy-4-phenoxy-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (1196395-39-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃;

DOI:10.1016/j.bmcl.2012.12.042

Reference yield:

phenylboronic acid (98-80-6) → 2-(2-methoxy-4-phenoxy-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (1196395-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate; triethylamine / dichloromethane / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; copper diacetate; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2012.12.042

Reference yield:

4-bromo-3-methoxyphenol (102127-34-4) → 2-(2-methoxy-4-phenoxy-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (1196395-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate; triethylamine / dichloromethane / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; copper diacetate; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2012.12.042

upstream raw materials:

4-bromo-3-methoxyphenol

bis(pinacol)diborane

phenylboronic acid

Downstream raw materials:

C₂₄H₂₄N₄O₃

Refernces

• 1、 -. "SUBSTITUTED IMIDAZOPYR- AND IMIDAZOTRI-AZINES". Page/Page column 53. . Retrieved 2009/12/05.