4-Nitrobenzoic acid 4-methoxybenzyl ester

Base Information

• Chemical Name: 4-Nitrobenzoic acid 4-methoxybenzyl ester
• CAS No.: 53218-10-3
• Molecular Formula: C15H13NO5
• Molecular Weight: 287.272
• Mol file: 53218-10-3.mol

Synonyms:4-Nitrobenzoic acid 4-methoxybenzyl ester

Chemical Property of 4-Nitrobenzoic acid 4-methoxybenzyl ester

Chemical Property:

• PSA: 81.35000
• LogP: 3.48360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Nitrobenzoic acid 4-methoxybenzyl ester

There total 9 articles about 4-Nitrobenzoic acid 4-methoxybenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-Methoxybenzyl alcohol (105-13-5) + 4-nitro-benzoic acid (62-23-7) → 4-methoxybenzyl 4-nitrobenzoate (53218-10-3)

Guidance literature:

With [bis(acetoxy)iodo]benzene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 16h;

DOI:10.1021/ja063141v

Reference yield: 81.0%

p-Methoxybenzyl bromide (2746-25-0) + 1-bromomethyl-4-nitro-benzene (100-11-8) → 4-methoxybenzyl 4-nitrobenzoate (53218-10-3)

Guidance literature:

With caesium carbonate; 1,4-dimethyl-1,2,4-triazolium iodide; In N,N-dimethyl acetamide; at 40 ℃; for 36h; Schlenk technique;

DOI:10.1002/anie.202011039

Reference yield: 65.0%

4-nitrobenzaldehdye (555-16-8) + 4-Methoxybenzyl alcohol (105-13-5) → 4-methoxybenzyl 4-nitrobenzoate (53218-10-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; vitamin B₁; In acetone; at 60 ℃; for 24h;

DOI:10.1039/d1ra05134b

upstream raw materials:

4-nitrobenzoic acid methyl ester

N,N-dimethyl-4-methoxylbenzylamine

4-nitro-benzoyl chloride

4-Methoxybenzyl alcohol

Downstream raw materials:

4-nitro-benzoic acid

5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole

4-methoxybenzyl 2,2,2-trifluoroethyl ether

Refernces

• 1、 Chu, Xue-Qiang,Ge, Danhua,Luo, Xin-Long,Xu, Pei,Yu, Zi-Lun. "Vitamin B1-catalyzed aerobic oxidative esterification of aromatic aldehydes with alcohols". supporting information. p. 30937 - 30942. Retrieved 2021/11/19.
• 2、 Buonomo, Joseph A.,Aldrich, Courtney C.. "Mitsunobu Reactions Catalytic in Phosphine and a Fully Catalytic System". supporting information. p. 13041 - 13044. Retrieved 2015/11/02.