Prasugrel alpha-Hydroxy IMpurity

Base Information

• Chemical Name: Prasugrel alpha-Hydroxy IMpurity
• CAS No.: 1100905-45-0
• Molecular Formula: C11H11FO2
• Molecular Weight: 194.206
• Mol file: 1100905-45-0.mol

Synonyms:Prasugrel alpha-Hydroxy IMpurity;1-cyclopropyl-2-(2-fluorophenyl)-2-hydroxyethanone

Chemical Property of Prasugrel alpha-Hydroxy IMpurity

Chemical Property:

• Boiling Point: 298.4±25.0 °C(Predicted)
• PKA: 11.78±0.20(Predicted)
• PSA: 37.30000
• Density: 1.315±0.06 g/cm3(Predicted)
• LogP: 1.83820

Purity/Quality:

99.0% Min ^*data from raw suppliers

1-Cyclopropyl-2-(2-fluorophenyl)-2-hydroxy-ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Prasugrel alpha-Hydroxy IMpurity

There total 1 articles about Prasugrel alpha-Hydroxy IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.6%

cyclopropyl bromide (4333-56-6,130561-87-4) + α-[(trimethylsilyl)oxy]-α-(o-fluorophenyl)acetonitrile (82128-76-5) → 2-hydroxy-1-cyclopropyl-2-(2-fluorophenyl)ethanone (1100905-45-0)

Guidance literature:

cyclopropyl bromide; With iodine; magnesium; In diethyl ether; at 20 ℃; for 3.5h; Reflux; Inert atmosphere;

α-[(trimethylsilyl)oxy]-α-(o-fluorophenyl)acetonitrile; In tetrahydrofuran; diethyl ether; at 20 - 28 ℃; for 19.5h; Inert atmosphere;

Reference yield: 94.2%

4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride (1151904-84-5) + 2-hydroxy-1-cyclopropyl-2-(2-fluorophenyl)ethanone (1100905-45-0) → CS-747 hydrochloride

Guidance literature:

With triphenylphosphine; N,N,N',N'-tetraisopropylazodicarboxamide; In dichloromethane; at 20 ℃; Solvent; Reagent/catalyst; Temperature; Concentration;

Reference yield: 85.0%

2-hydroxy-1-cyclopropyl-2-(2-fluorophenyl)ethanone (1100905-45-0) + methanesulfonyl chloride (124-63-0) → 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate (1100905-46-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 2 ℃;

upstream raw materials:

cyclopropyl bromide

α-[(trimethylsilyl)oxy]-α-(o-fluorophenyl)acetonitrile

Downstream raw materials:

3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate

Refernces