6a,7,10,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol

Base Information

• Chemical Name: 6a,7,10,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol
• CAS No.: 14132-18-4
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 314.468
• Mol file: 14132-18-4.mol

Synonyms:6a,7,10,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol

Chemical Property of 6a,7,10,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol

Chemical Property:

• PSA: 29.46000
• LogP: 5.73580

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6a,7,10,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol

There total 13 articles about 6a,7,10,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.7%

cannabidiol (3556-78-3,7663-52-7,13956-29-1,13956-30-4,22703-18-0,25753-43-9,35542-48-4,74219-29-7,521-37-9) → (6aS,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol (43009-38-7) + tetrahydrocannabinol (16849-50-6) + 6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol (14132-18-4) + iso-Δ8-tetrahydrocannabinol (6909-05-3)

Guidance literature:

benzoic acid ; diisobutyl aluminium-benzoate; In dichloromethane; at 20 ℃; for 22h;

Reference yield:

(+)-p-mentha-2,8-dien-1-ol (22771-44-4,3886-78-0,4017-73-6,7212-40-0,22972-51-6,52154-82-2,82769-01-5) + Olivetol (500-66-3) → 6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol (14132-18-4)

Guidance literature:

(+)-p-mentha-2,8-dien-1-ol; Olivetol; With methanesulfonic acid; In dichloromethane; for 4h; Heating / reflux;

With sodium hydrogencarbonate; In dichloromethane; water; at 25 ℃;

Reference yield:

(+)-p-mentha-2,8-dien-1-ol (22771-44-4,3886-78-0,4017-73-6,7212-40-0,22972-51-6,52154-82-2,82769-01-5) → tetrahydrocannabinol (16849-50-6) + 6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol (14132-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc trifluoromethanesulfonate / dichloromethane / 60 °C

1.2: 20 h

2.1: diisobutylaluminum acetate / dichloromethane / 22 h / 20 °C

With zinc trifluoromethanesulfonate; diisobutylaluminum acetate; In dichloromethane;

upstream raw materials:

(+)-p-mentha-2,8-dien-1-ol

Olivetol

cannabidiol

(+)-limonene oxide

Refernces

• 1、 -. "METHODS FOR PURIFYING TRANS-(-)-Δ9-TETRAHYDROCANNABINOL AND TRANS-(+)-Δ9-TETRAHYDROCANNABINOL". Page/Page column 44. . Retrieved 2008/06/13.