5-Chloro-2,3-dimethylpyrazine

Base Information

• Chemical Name: 5-Chloro-2,3-dimethylpyrazine
• CAS No.: 59489-32-6
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.58618
• Hs Code.: 2933990090
• European Community (EC) Number: 810-068-0
• DSSTox Substance ID: DTXSID10503976
• Wikidata: Q72449574
• Mol file: 59489-32-6.mol

Synonyms:5-Chloro-2,3-dimethylpyrazine;59489-32-6;MFCD13189517;2-chloro-5,6-dimethylpyrazine;SCHEMBL609820;5-chloro-2,3-dimethyl pyrazine;DTXSID10503976;MEWMQKSSLANHCR-UHFFFAOYSA-N;AKOS016002783;AB68573;CS-W022343;DS-3533;SY111270;EN300-154935;Y10049;A869190;Z1255462913

Chemical Property of 5-Chloro-2,3-dimethylpyrazine

Chemical Property:

• Boiling Point: 81℃ (18 Torr)
• Flash Point: 90.3±11.5℃
• PSA: 25.78000
• Density: 1.184±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 1.74680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 142.0297759
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

98%Min ^*data from raw suppliers

5-chloro-2,3-dimethylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C(N=C1C)Cl

Technology Process of 5-Chloro-2,3-dimethylpyrazine

There total 5 articles about 5-Chloro-2,3-dimethylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2,3-dimethyl-1,4-diazine N-oxide (65464-21-3) → 2-chloro-5,6-dimethylpyrazine (59489-32-6) + 2-Chloromethyl-3-methylpyrazine (81831-67-6)

Guidance literature:

With trichlorophosphate; for 0.5h; Heating;

Reference yield:

2,3-dimethyl-1,4-diazine N-oxide (65464-21-3) → 2-chloro-5,6-dimethylpyrazine (59489-32-6)

Guidance literature:

2,3-dimethyl-1,4-diazine N-oxide; With trichlorophosphate; at 110 ℃; for 1h;

With potassium hydroxide; In water; pH=~ 8;

Reference yield:

2,3-Dimethyl-5-hydroxypyrazine (57229-36-4) → 2-chloro-5,6-dimethylpyrazine (59489-32-6)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/ja01126a070

upstream raw materials:

2,3-Dimethyl-5-hydroxypyrazine

4,5-dimethylimidazole

chloroform

2,3-dimethyl-1,4-diazine N-oxide

Downstream raw materials:

2,3-Dimethyl-5-hydroxypyrazine

5,6-Dichloro-2,3-dimethylpyrazine

2,3-dimethyl-5-[(phenylmethyl)oxy]pyrazine

Refernces

• 1、 -. "3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS". Page/Page column 70-71. . Retrieved 2010/11/05.
• 2、 Watahiki, Hiroko,Tsutsui, Mayumi,Akita, Yasuo,Watanabe, Tokuhiro,Kurihara, Teruo. "Syntheses and Reactions of Some 2,3-Disubstituted Pyrazine Monoxides". . p. 465 - 473. Retrieved 2007/10/02.