4-chloro-2-fluoro-5-nitrobenzoyl chloride

Base Information

• Chemical Name: 4-chloro-2-fluoro-5-nitrobenzoyl chloride
• CAS No.: 947311-91-3
• Molecular Formula: C₇H₂Cl₂FNO₃
• Molecular Weight: 238.002
• Mol file: 947311-91-3.mol

Synonyms:4-chloro-2-fluoro-5-nitrobenzoyl chloride

Chemical Property of 4-chloro-2-fluoro-5-nitrobenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-fluoro-5-nitrobenzoyl chloride

There total 1 articles about 4-chloro-2-fluoro-5-nitrobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-fluoro-5-nitro-benzoic acid (35112-05-1) → 4-chloro-2-fluoro-5-nitro-benzoyl chloride (947311-91-3)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b00082

Reference yield:

4-chloro-2-fluoro-5-nitro-benzoyl chloride (947311-91-3) + N,2-dimethylaniline (611-21-2) → 4-chloro-2-fluoro-N-methyl-5-nitro-N-o-tolyl-benzamide (1070892-48-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 12h;

Reference yield:

4-chloro-2-fluoro-5-nitro-benzoyl chloride (947311-91-3) → 4-[5-chloro-2-(methyl-o-tolyl-carbamoyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-butyric acid tert-butyl ester (1070892-54-4)

Guidance literature:

Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 12 h / 0 °C

2: sodium dithionite; water / tetrahydrofuran / 12 h

3: n-Butyl nitrite; copper(ll) bromide / acetonitrile / 2 h / 65 °C

4: methanol / 12 h / 55 °C

5: boron tribromide / dichloromethane / 12 h / -78 - 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

7: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 95 °C

With sodium dithionite; n-Butyl nitrite; water; potassium acetate; boron tribromide; potassium carbonate; triethylamine; copper(ll) bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

4-chloro-2-fluoro-5-nitro-benzoic acid

Downstream raw materials:

4-chloro-2-fluoro-N-methyl-5-nitro-N-o-tolyl-benzamide

(2S,2'S)-di-tert-butyl 2,2'-(6,6'-((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(5-fluoro-1H-benzo[d]imidazole-6,2-diyl))bis(pyrrolidine-1-carboxylate)

(S)-6,6'-((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(5-fluoro-2-((S)pyrrolidin-2-yl)-1hbenzo[d]imidazole)

Refernces

• 1、 -. "GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO". Page/Page column 88. . Retrieved 2008/12/04.