Cinacalcet IMpurity

Base Information

• Chemical Name: Cinacalcet IMpurity
• CAS No.: 1229224-93-4
• Molecular Formula: C22H26F3N
• Molecular Weight: 361.45
• Mol file: 1229224-93-4.mol

Synonyms:Cinacalcet IMpurity;1-NaphthaleneMethanaMine, 5,6,7,8-tetrahydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-, (αR)-;(R)-N-[1-(5,6,7,8-Tetrahydronaphthalen-1-yl)ethyl]-3-[3-(trifluoroMethyl)phenyl]-1-propylaMine;Cinacalcet Impurity 12 Hydrochloride;Cinacalcet Impurity 13;Cinacalcet Impurity 15;Cinacalcet Impurity 16;Cinacalcet Impurity 17

Chemical Property of Cinacalcet IMpurity

Chemical Property:

• Boiling Point: 428.1±45.0 °C(Predicted)
• PKA: 9.57±0.29(Predicted)
• PSA: 12.03000
• Density: 1.121±0.06 g/cm3(Predicted)
• LogP: 6.25850
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%+, ^*data from raw suppliers

(R)-N-[1-(5,6,7,8-Tetrahydronaphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cinacalcet IMpurity

There total 1 articles about Cinacalcet IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cinacalcet (226256-56-0,694495-47-1) → (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methane amine (1229224-93-4)

Guidance literature:

With hydrogen; Raney-Ni; In methanol; at 75 - 80 ℃; for 16h; under 8826.87 - 11033.6 Torr;

Reference yield:

(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methane amine (1229224-93-4) → (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methane amine hydrochloride (1229225-43-7)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 25 - 30 ℃;

upstream raw materials:

cinacalcet

Downstream raw materials:

(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methane amine hydrochloride

Refernces