Technology Process of trans-Capsaicin-d3
There total 6 articles about trans-Capsaicin-d3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trans-8-methyl-6-nonenoic acid;
With
N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.25h;
4-(aminomethyl)-2-methoxy-d3-phenol hydrochloride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
4-(aminomethyl)-2-methoxy-d3-phenol hydrochloride;
With
sodium hydroxide;
In
water;
(E)-8-Methylnon-6-enoic acid chloride;
In
tetrahydrofuran;
at 20 ℃;
Reflux;
DOI:10.1002/jlcr.1678
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile / 0.08 h
1.2: 6 h / 60 °C
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.08 h / 0 °C
2.2: 1 h / 20 °C
3.1: hydroxylamine hydrochloride; sodium acetate / acetonitrile; water / 2 h / Reflux
4.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; ethanol / 3 h / 20 °C / 1551.49 Torr
5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C
5.2: 2 h / 0 - 20 °C
With
hydrogenchloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
