2,4-DIHYDROXY-6-AMINO-5-DIETHOXYETHYLPYRIMIDINE

Base Information

• Chemical Name: 2,4-DIHYDROXY-6-AMINO-5-DIETHOXYETHYLPYRIMIDINE
• CAS No.: 102879-75-4
• Molecular Formula: C10H17N3O4
• Molecular Weight: 243.25968
• Mol file: 102879-75-4.mol

Synonyms:2,4-DIHYDROXY-6-AMINO-5-DIETHOXYETHYLPYRIMIDINE;4-AMino-2,6-dihydroxy-5-pyriMidineacetaldehyde Diethyl Acetal;6-AMino-5-(2,2-diethoxyethyl)-2,4(1H,3H)-pyriMidinedione

Chemical Property of 2,4-DIHYDROXY-6-AMINO-5-DIETHOXYETHYLPYRIMIDINE

Chemical Property:

• PKA: 3.89±0.10(Predicted)
• PSA: 110.72000
• Density: 1.186±0.06 g/cm3(Predicted)
• LogP: 0.99280
• Solubility.: DMF, DMSO

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dihydroxy-6-amino-5-diethoxyethylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dihydroxy-6-amino-5-diethoxyethylpyrimidine (cas# 102879-75-4) is a compound useful in organic synthesis.

Technology Process of 2,4-DIHYDROXY-6-AMINO-5-DIETHOXYETHYLPYRIMIDINE

There total 2 articles about 2,4-DIHYDROXY-6-AMINO-5-DIETHOXYETHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

ethyl 2-cyano-4,4-diethoxybutyrate (52133-67-2) + urea (57-13-6) → 4-Amino-2,6-dihydroxy-5-(2,2-diethoxy-ethyl)-pyrimidin (102879-75-4)

Guidance literature:

ethyl 2-cyano-4,4-diethoxybutyrate; urea; With sodium ethanolate; In ethanol; Heating / reflux;

With ethanol; water; acetic acid; at 20 ℃;

Reference yield:

→ 4-Amino-2,6-dihydroxy-5-(2,2-diethoxy-ethyl)-pyrimidin (102879-75-4)

Guidance literature:

(2,2-Diethoxy-ethyl)-cyanessigsaeure-ethylester, Harnstoff, Natriumethylat-Lsg., Kochen, 3-4 h;

DOI:10.1039/jr9600000131

Reference yield: 80.0%

4-Amino-2,6-dihydroxy-5-(2,2-diethoxy-ethyl)-pyrimidin (102879-75-4) → pyrrolo<2,3-d>pyrimidin-2,4-dione (39929-79-8)

Guidance literature:

With hydrogenchloride; water; at 20 ℃; for 1.5h;

upstream raw materials:

ethyl 2-cyano-4,4-diethoxybutyrate

urea

Downstream raw materials:

pyrrolo<2,3-d>pyrimidin-2,4-dione

Refernces