1-(Phenylsulfonyl)-4-chloro-5-azaindole

Base Information

• Chemical Name: 1-(Phenylsulfonyl)-4-chloro-5-azaindole
• CAS No.: 209286-78-2
• Molecular Formula: C13H9ClN2O2S
• Molecular Weight: 292.74076
• Mol file: 209286-78-2.mol

Synonyms:1-(Phenylsulfonyl)-4-chloro-5-azaindole

Chemical Property of 1-(Phenylsulfonyl)-4-chloro-5-azaindole

Chemical Property:

• Boiling Point: 510.0±53.0 °C(Predicted)
• PKA: 3.98±0.30(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(Phenylsulfonyl)-4-chloro-5-azaindole

There total 5 articles about 1-(Phenylsulfonyl)-4-chloro-5-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine-5-oxide → 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[3,2-c]pyridine (209286-78-2)

Guidance literature:

With trichlorophosphate; at 0 - 90 ℃; for 18h;

Reference yield:

4-chloro-1H-pyrrolo-[3,2-c]-pyridine (60290-21-3) → 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[3,2-c]pyridine (209286-78-2)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogen sulfate; benzenesulfonyl chloride; In dichloromethane;

Reference yield:

5-azaindole (271-34-1) → 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[3,2-c]pyridine (209286-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 35 °C

1.2: 2.17 h / 0 - 35 °C

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 24 h / 10 - 35 °C

3.1: trichlorophosphate / 18 h / 0 - 90 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; chloroform; mineral oil;

upstream raw materials:

4-chloro-1H-pyrrolo-[3,2-c]-pyridine

benzenesulfonyl chloride

5-azaindole

1-Benzenesulfonyl-1H-pyrrolo<3,2-c>pyridine

Refernces

• 1、 -. "3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF". . . Retrieved 2017/03/08.
• 2、 -. "3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF". . . Retrieved 2017/02/28.