CefixiMe Methyl Ester

Base Information

• Chemical Name: CefixiMe Methyl Ester
• CAS No.: 88621-01-6
• Molecular Formula: C17H17N5O7S2
• Molecular Weight: 467.483
• Mol file: 88621-01-6.mol

Synonyms:CefixiMe Methyl Ester

Chemical Property of CefixiMe Methyl Ester

Chemical Property:

• PKA: 2.79±0.50(Predicted)
• PSA: 227.05000
• Density: 1.73±0.1 g/cm3(Predicted)
• LogP: 0.45360
• Solubility.: Methanol

Purity/Quality:

99% ^*data from raw suppliers

CefiximeMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Cefixime Methyl Ester is an ester impurity of the third generation cephalosporin antibiotic, Cefixime (C242800). Cefixime Methyl Ester is an intermediate in the synthesis of Cefixime (C242800), an orally active, third generation cephalosporin antibiotic.

Technology Process of CefixiMe Methyl Ester

There total 6 articles about CefixiMe Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H18N3O7PS2 + (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (79349-82-9) → 7-{2-[(2-aminothiazol)-4-yl]-2-[(Z)(methoxycarbonyl)methoxyimino]acetamido}-3-vinyl-ceph-3-em-4-carboxylic acid (88621-01-6)

Guidance literature:

With sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; water; at 5 - 10 ℃; for 6h; Reagent/catalyst;

Reference yield:

7-{2-[(2-aminothiazol)-4-yl]-2-[(Z)(methoxycarbonyl)methoxyimino]acetamido}-3-vinyl-ceph-3-em-4-carboxylic acid tert.octylamine salt → 7-{2-[(2-aminothiazol)-4-yl]-2-[(Z)(methoxycarbonyl)methoxyimino]acetamido}-3-vinyl-ceph-3-em-4-carboxylic acid (88621-01-6)

Guidance literature:

7-{2-[(2-aminothiazol)-4-yl]-2-[(Z)(methoxycarbonyl)methoxyimino]acetamido}-3-vinyl-ceph-3-em-4-carboxylic acid tert.octylamine salt; With sodium hydroxide; In water; at 0 ℃;

With hydrogenchloride; isoascorbic acid; In water; pH=3.5; Product distribution / selectivity;

Reference yield:

C15H12N4O4S3 + (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (79349-82-9) → 7-{2-[(2-aminothiazol)-4-yl]-2-[(Z)(methoxycarbonyl)methoxyimino]acetamido}-3-vinyl-ceph-3-em-4-carboxylic acid (88621-01-6)

Guidance literature:

With triethylamine; In water; at 30 - 35 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

thiourea

2-(2-aminothiazol-4-yl)-2-[(Z)-methoxycarbonylmethoxyimino]acetic acid

Downstream raw materials:

cefixime

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF CEFIXIME". Page/Page column 8-9. . Retrieved 2008/06/13.