K 76 terpene

Base Information

• Chemical Name: K 76 terpene
• CAS No.: 72657-13-7
• Molecular Formula: C₂₃H₃₀O₆
• Molecular Weight: 402.488
• Mol file: 72657-13-7.mol

Synonyms:K-76;

Chemical Property of K 76 terpene

Chemical Property:

• PSA: 104.06000
• LogP: 2.89500

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of K 76 terpene

There total 9 articles about K 76 terpene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C25H34O7 (83025-42-7) → (+/-)-K-76 (70016-70-5,72657-13-7,83059-27-2,111264-82-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 23 ℃; for 1h;

DOI:10.1021/ja00384a075

Reference yield: 38.0%

O-methyl K-76 (111264-71-2) → (-)-K-76 (72657-13-7)

Guidance literature:

With n-butyllithium; hexane; 2-methylpropanethiol-1; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 12h; Ambient temperature;

Reference yield:

C25H35NO7 → (+/-)-K-76 (70016-70-5,72657-13-7,83059-27-2,111264-82-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 0.02percent tosic acid / 1 h / 23 °C

2: tosic acid / acetone / 1 h / 23 °C

3: dinitrogen tetraoxide, sodium acetate / CCl₄ / 0.5 h / 0 °C

4: diisobutylaluminium hydride / toluene / 0.17 h / -78 °C

5: 1 N hydrochloric acid / tetrahydrofuran / 0.5 h / 23 °C

6: 87 percent / 6 N hydrochloric acid / tetrahydrofuran / 1 h / 23 °C

With hydrogenchloride; sodium acetate; dinitrogen tetraoxide; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; tetrachloromethane; acetone; toluene;

DOI:10.1021/ja00384a075

upstream raw materials:

C₂₅H₃₄O₇

C₂₉H₄₁NO₇

C₂₇H₄₁NO₈

C₂₉H₄₀O₈

Refernces

• 1、 Corey, E. J.,Das, Jagabandhu. "Total Synthesis of the Complement Inhibitor K-76 in Racemic Form. Structural Assignment to "K-76 Monocarboxylic Acid"". . p. 5551 - 5553. Retrieved 2007/10/02.