POTASSIUM BROMODIFLUOROACETATE

Base Information

• Chemical Name: POTASSIUM BROMODIFLUOROACETATE
• CAS No.: 87189-16-0
• Molecular Formula: C2BrF2KO2
• Molecular Weight: 213.02
• Hs Code.: 2915900090
• Mol file: 87189-16-0.mol

Synonyms:POTASSIUM BROMODIFLUOROACETATE;Potassium2-bromo-2,2-difluoroacetate;Potassium bromo(difluoro)acetate 97+%

Chemical Property of POTASSIUM BROMODIFLUOROACETATE

Chemical Property:

• PSA: 40.13000
• LogP: -0.27600
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

PotassiumBromodifluoroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of POTASSIUM BROMODIFLUOROACETATE

There total 1 articles about POTASSIUM BROMODIFLUOROACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Ethyl bromodifluoroacetate (667-27-6) → potassium 2-bromo-2,2-difluoroacetate (87189-16-0)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃;

DOI:10.1016/j.jfluchem.2014.04.011

Reference yield: 95.0%

potassium 2-bromo-2,2-difluoroacetate (87189-16-0) + triphenylphosphine (603-35-0) → 2,2‐difluoro‐2‐(triphenylphosphonio)acetate

Guidance literature:

In N,N-dimethyl-formamide; at 25 ℃; for 10h; Sealed tube;

Reference yield: 95.0%

potassium 2-bromo-2,2-difluoroacetate (87189-16-0) + triphenylphosphine (603-35-0) → C20H16F2O2P

Guidance literature:

In ethanol; at 40 ℃; for 20h;

upstream raw materials:

Ethyl bromodifluoroacetate

Downstream raw materials:

iododifluoromethane

difluorodiiodomethane

C₈H₇BrF₂Zn

1-Phenylbut-1-en-3-one

Refernces

• 1、 Chen, Xiaoyu,Liu, Bo,Pei, Congcong,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng. "Visible-Light-Induced Radical Difluoromethylation/Cyclization of Unactivated Alkenes: Access to CF2H-Substituted Quinazolinones". supporting information. p. 7787 - 7791. Retrieved 2021/10/20.
• 2、 Ashworth, Sharon,Boscutti, Giulia,Chupin, Juliette,Cornelissen, Bart,Davis, Benjamin G.,Guibbal, Florian,Isenegger, Patrick G.,Kashani, Roxana,Kee, Choon Wee,Macholl, Sven,Passchier, Jan,Plisson, Christophe,Poh, Adeline W. J.,Sosabowski, Jane K.,Tack, Osman,Tilby, Michael,Verhoog, Stefan,Willis, Michael C.,Wilson, Thomas C.,Gouverneur, Véronique,Imio?ek, Mateusz. "18F-Trifluoromethanesulfinate Enables Direct C-H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides". supporting information. . Retrieved 2020/02/04.