2-fluoropropane-1,3-diaMine

Base Information

• Chemical Name: 2-fluoropropane-1,3-diaMine
• CAS No.: 159029-28-4
• Molecular Formula: C3H9FN2
• Molecular Weight: 92.1163
• Mol file: 159029-28-4.mol

Synonyms:2-fluoropropane-1,3-diaMine;1,3-diamino-2-fluoropropane

Chemical Property of 2-fluoropropane-1,3-diaMine

Chemical Property:

• Boiling Point: 168.1±20.0 °C(Predicted)
• PKA: 8.74±0.10(Predicted)
• PSA: 52.04000
• Density: 1.009±0.06 g/cm3(Predicted)
• LogP: 0.64250

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-fluoropropane-1,3-diamine, a chemical compound, has diverse applications across various fields. In the pharmaceutical and medicinal sector, it is utilized as a key intermediate in the synthesis of pharmaceuticals and organic molecules with potential therapeutic properties. Researchers often incorporate it into the molecular structure of drug candidates to modify their biological activity and enhance their efficacy. Additionally, in the field of agrochemicals, it can play a role in the development of crop protection agents and pesticides, contributing to agriculture and pest control. Its importance also extends to materials science, where it can be used as a building block for the creation of specialized polymers and compounds with unique properties. 2-fluoropropane-1,3-diamine's versatility makes it a valuable tool in chemical synthesis, drug discovery, and materials development, supporting advancements in various scientific and industrial applications.

Technology Process of 2-fluoropropane-1,3-diaMine

There total 3 articles about 2-fluoropropane-1,3-diaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-fluoropropanediamide (815-59-8) → 1,3-diamino-2-fluoropropane (159029-28-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 70 ℃;

Reference yield:

bis-N-benzyloxycarbonyl-2-fluoro-1,3-diaminopropane (247102-06-3) → 1,3-diamino-2-fluoropropane (159029-28-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; at 20 ℃; for 16h; under 2585.81 Torr;

Reference yield:

N,N,N',N'-tetrabenzyl-1,3-diamino-2-fluoropropane (726190-66-5) → 1,3-diamino-2-fluoropropane (159029-28-4)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; ethyl acetate; for 40h; under 2585.81 Torr;

DOI:10.1016/j.bmc.2007.03.034

upstream raw materials:

N,N,N',N'-tetrabenzyl-1,3-diamino-2-fluoropropane

bis-N-benzyloxycarbonyl-2-fluoro-1,3-diaminopropane

2-fluoropropanediamide

Downstream raw materials:

3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-nitrobenzoic acid

N-(5-fluoro-1,4,5,6-tetrahydropyrimidin-2-yl)-3-aminobenzoic acid

3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]-5-hydroxybenzoic acid

Refernces

• 1、 -. "COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE". Page/Page column 21. . Retrieved 2013/04/25.
• 2、 -. "THE R-ISOMER OF BETA AMINO ACID COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES". Page/Page column 121. . Retrieved 2010/02/07.