2-(4-BROMOPHENYL)-2-OXOETHYL ACETATE

Base Information

• Chemical Name: 2-(4-BROMOPHENYL)-2-OXOETHYL ACETATE
• CAS No.: 7500-37-0
• Molecular Formula: C10H9BrO3
• Molecular Weight: 257.084
• Hs Code.: 2915390090
• Mol file: 7500-37-0.mol

Synonyms:2-(4-bromophenyl)-2-oxoethyl acetate;

Chemical Property of 2-(4-BROMOPHENYL)-2-OXOETHYL ACETATE

Chemical Property:

• Vapor Pressure: 9.67E-05mmHg at 25°C
• Melting Point: 84-86℃
• Refractive Index: 1.546
• Boiling Point: 338.7 °C at 760 mmHg
• Flash Point: 158.6 °C
• PSA: 43.37000
• Density: 1.48 g/cm³
• LogP: 2.19490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Bromophenyl)-2-oxoethylacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-BROMOPHENYL)-2-OXOETHYL ACETATE

There total 31 articles about 2-(4-BROMOPHENYL)-2-OXOETHYL ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

potassium acetate (127-08-2) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 2-(4-bromophenyl)-2-oxoethyl acetate (7500-37-0)

Guidance literature:

With Tris(3,6-dioxaheptyl)amine; In acetonitrile; for 0.25h; Heating;

Reference yield: 95.3%

acetic acid (64-19-7,77671-22-8) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 2-(4-bromophenyl)-2-oxoethyl acetate (7500-37-0)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1021/ac50064a047

Reference yield: 95.0%

sodium acetate (127-09-3) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 2-(4-bromophenyl)-2-oxoethyl acetate (7500-37-0)

Guidance literature:

With 1,3-dimethylimidazolinium methanesulfonate; at 90 ℃; for 1h;

DOI:10.1016/S0040-4039(03)00179-5

upstream raw materials:

1-(4-bromo-phenyl)-2-diazo-ethanone

acetic acid

sodium acetate

para-bromophenacyl bromide

Downstream raw materials:

2-(4-Bromo-phenyl)-4-methyl-morpholine

(R)-2-hydroxy-2-(4-bromophenyl)ethyl acetate

(S)-2-methylcarbonyloxy-1-(4-bromophenyl)ethyl acetate

C₁₈H₁₄BrNO₃

Refernces

• 1、 Chen, Xin,Xin, Yangchun,Zhao, Zhi-Wei,Hou, Yu-Jian,Wang, Xiang-Xiang,Xia, Wen-Jin,Li, Ya-Min. "Decarboxylative Oxyacyloxylation of Propiolic Acids: Construction of Alkynyl-Containing α-Acyloxy Ketones". . p. 8216 - 8225. Retrieved 2021/06/28.
• 2、 Mahato, Sachinta,Santra, Sougata,Zyryanov, Grigory V.,Majee, Adinath. "Metal-Free Amidation Reactions of Terminal Alkynes with Benzenesulfonamide". . . Retrieved 2019/03/19.