PACLITAXEL-D5

Base Information

• Chemical Name: PACLITAXEL-D5
• CAS No.: 1129540-33-5
• Molecular Formula: C47H46D5NO14
• Molecular Weight: 858.94
• Mol file: 1129540-33-5.mol

Synonyms:TAXOL-D5;PACLITAXEL-D5;Abraxane-d5

Chemical Property of PACLITAXEL-D5

Chemical Property:

• Melting Point: 154-156°C
• PSA: 224.78000
• LogP: 4.31050
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Paclitaxel-d5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: PACLITAXEL-D5 is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Labelled Paclitaxel (P132500). An antineoplastic. Used in the study of structure and function of microtubles into tubulin.

Technology Process of PACLITAXEL-D5

There total 4 articles about PACLITAXEL-D5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.4%

benzoyl chloride-d5 (43019-90-5) + 13-(O-2R-hydroxy-3S-amine-phenylpropionyl)-baccatin III (133524-70-6) → C47H46(2)H5NO14 (1129540-33-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Cooling with ice;

DOI:10.1002/jlcr.1870

Reference yield:

C59H75NO16Si (1315376-84-1) → C47H46(2)H5NO14 (1129540-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid / 2 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With formic acid; triethylamine; In dichloromethane;

DOI:10.1002/jlcr.1870

Reference yield:

baccatin III (27548-93-2) → C47H46(2)H5NO14 (1129540-33-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 8 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / toluene / 2 h / 20 - 80 °C

3: formic acid / 2 h / 20 °C

4: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With dmap; formic acid; triethylamine; dicyclohexyl-carbodiimide; In pyridine; dichloromethane; toluene;

DOI:10.1002/jlcr.1870

upstream raw materials:

C₅₉H₇₅NO₁₆Si

benzoyl chloride-d5

13-(O-2R-hydroxy-3S-amine-phenylpropionyl)-baccatin III

baccatin III

Downstream raw materials:

C₅₃H₅₈⁽²⁾H₅NO₁₃Si

C₅₃H₆₀⁽²⁾H₅NO₁₄Si

Refernces