Technology Process of Tedatioxetine
There total 6 articles about Tedatioxetine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
water; ethyl acetate;
for 0.25h;
pH=13 - 14;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen bromide; acetic acid / 18 h / 80 °C
2: sodium hydroxide / ethyl acetate / 0.25 h / pH 13 - 14
With
hydrogen bromide; acetic acid; sodium hydroxide;
In
ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 120 °C / Inert atmosphere
2.1: n-butyllithium / n-heptane; hexane / 1.17 h / 20 °C / Inert atmosphere
2.2: -40 °C
3.1: hydrogen bromide; acetic acid / 18 h / 80 °C
4.1: sodium hydroxide / ethyl acetate / 0.25 h / pH 13 - 14
With
n-butyllithium; potassium tert-butylate; hydrogen bromide; acetic acid; sodium hydroxide;
In
1-methyl-pyrrolidin-2-one; hexane; n-heptane; ethyl acetate;
