ethyl 2-bromo-2-p-tolylacetate

Base Information

• Chemical Name: ethyl 2-bromo-2-p-tolylacetate
• CAS No.: 15674-78-9
• Molecular Formula: C₁₁H₁₃BrO₂
• Molecular Weight: 257.127
• Mol file: 15674-78-9.mol

Synonyms:ethyl 2-bromo-2-p-tolylacetate

Chemical Property of ethyl 2-bromo-2-p-tolylacetate

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-bromo-2-p-tolylacetate

There total 19 articles about ethyl 2-bromo-2-p-tolylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethanol (64-17-5) + 3-p-Tolyl-oxirane-2,2-dicarbonitrile (102862-46-4) → (+/-)-α-bromo-p-tolylacetic acid ethyl ester (15674-78-9)

Guidance literature:

With hydrogen bromide; for 3h; Heating;

DOI:10.1016/S0040-4020(01)90607-6

Reference yield: 79.0%

p-methylphenyldiazoacetic acid ethyl ester (27668-90-2) → (+/-)-α-bromo-p-tolylacetic acid ethyl ester (15674-78-9)

Guidance literature:

With cobalt(II) bromide hexahydrate; In 1,4-dioxane; at 100 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1002/adsc.202000009

Reference yield: 78.0%

hydroxy-p-tolyl-acetic acid ethyl ester (18584-23-1) → (+/-)-α-bromo-p-tolylacetic acid ethyl ester (15674-78-9)

Guidance literature:

With phosphorus tribromide; In tetrachloromethane; for 1h; Heating;

upstream raw materials:

ethanol

3-p-Tolyl-oxirane-2,2-dicarbonitrile

p-tolylacetic acid ethyl ester

hydroxy-p-tolyl-acetic acid ethyl ester

Downstream raw materials:

(+/-)-6-p-Tolylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one

N,N-dibenzyl-2-((tert-butyl)dimethylsilyloxy)-2-ethoxy-1-(p-tolyl)ethenamine

ethyl 2-(dibenzylamino)-2-(p-tolyl)butanoate

Refernces

• 1、 Wang, Haifeng,Sun, Xiangli,Hu, Manman,Zhang, Xiaoyi,Xie, Lele,Gu, Shuangxi. "Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide". supporting information. p. 3347 - 3351. Retrieved 2020/07/04.
• 2、 Hata, Shingo,Koyama, Hiroshi,Shimizu, Makoto. "Synthesis of α,α-disubstituted α-amino esters: Nucleophilic addition to iminium salts generated from amino ketene silyl acetals". experimental part. p. 9670 - 9677. Retrieved 2012/01/04.