3-chloro-N-1,3-thiazol-2-ylpropanamide

Base Information

• Chemical Name: 3-chloro-N-1,3-thiazol-2-ylpropanamide
• CAS No.: 26774-38-9
• Molecular Formula: C₆H₇ClN₂OS
• Molecular Weight: 190.653
• Hs Code.: 2934100090
• Mol file: 26774-38-9.mol

Synonyms:3-chloro-N-1,3-thiazol-2-ylpropanamide;AKOS BB416;ASISCHEM D51480;UKRORGSYN-BB BBV-031285;3-chloro-N-1,3-thiazol-2-ylpropanamide(SALTDATA: FREE);3-chloro-N-(2-thiazolyl)propanamide;3-chloro-N-thiazol-2-yl-propanamide;3-chloro-N-thiazol-2-yl-propionamide

Chemical Property of 3-chloro-N-1,3-thiazol-2-ylpropanamide

Chemical Property:

• Melting Point: 169 °C
• PKA: 8.83±0.50(Predicted)
• PSA: 70.23000
• Density: 1.432g/cm³
• LogP: 1.78350

Purity/Quality:

98%min ^*data from raw suppliers

3-chloro-N-1,3-thiazol-2-ylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-N-1,3-thiazol-2-ylpropanamide

There total 2 articles about 3-chloro-N-1,3-thiazol-2-ylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-thiazolylamine (96-50-4) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-N-(1,3-thiazol-2-yl)propanamide (26774-38-9)

Guidance literature:

2-thiazolylamine; With sodium hydride; In tetrahydrofuran; mineral oil; for 6h; Inert atmosphere;

2-chloropropionyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2013.04.076

Reference yield:

→ 3-chloro-N-(1,3-thiazol-2-yl)propanamide (26774-38-9)

Guidance literature:

aus 3-Chloropropionylchlorid u. 2-Aminothiazol;

Reference yield: 75.0%

3-chloro-N-(1,3-thiazol-2-yl)propanamide (26774-38-9) + diphenylamine (122-39-4) → 3-Diphenylamino-N-thiazol-2-yl-propionamide (76099-62-2)

Guidance literature:

In ethanol; for 6h; Heating;

upstream raw materials:

2-thiazolylamine

2-chloropropionyl chloride

Downstream raw materials:

S-2-(<2-(2-Thiazolylcarbamoyl)ethyl>amino)ethyl hydrogenthiosulfat

5,6-Dihydro-7H-thiazolo<3,2-a>pyrimidin-7-on

3-Diphenylamino-N-thiazol-2-yl-propionamide

3-Dibenzylamino-N-thiazol-2-yl-propionamide

Refernces

• 1、 Zablotskaya,Segal,Germane,Shestakova,Domracheva,Nesterova,Geronikaki,Lukevics. "Silyl modification of biologically active compounds. 8. Trimethylsilyl ethers of hydroxyl-containing thiazole derivatives". . p. 859 - 866. Retrieved 2002.
• 2、 El-Messery, Shahenda M.,Hassan, Ghada S.,Al-Omary, Fatmah A.M.,El-Subbagh, Hussein I.. "Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido- and 2 or 3-propanamido-thiazole analogs". experimental part. p. 615 - 625. Retrieved 2012/09/21.