Nafcillin sodium salt monohydrate

Base Information

• Chemical Name: Nafcillin sodium salt monohydrate
• CAS No.: 7177-50-6
• Molecular Formula: C21H23N2NaO6S
• Molecular Weight: 414.4748
• Hs Code.: 29411099
• Mol file: 7177-50-6.mol

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-, monosodium salt,monohydrate (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodiumsalt, monohydrate, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodiumsalt, monohydrate, [2S-(2a,5a,6b)]-;Nafcillin sodium hydrate;Sodium6-(2-ethoxy-1-naphthamido)penicillanate monohydrate;Sodium nafcillinmonohydrate;

Chemical Property of Nafcillin sodium salt monohydrate

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 2.11E-21mmHg at 25°C
• Boiling Point: 714.1 °C at 760 mmHg
• Flash Point: 385.7 °C
• PSA: 133.30000
• Density: 1.42 g/cm³
• LogP: 1.41360
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble50mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nafcillin sodium monohydrate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-42/43
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Sodium Nafcillin Monohydrate is used as an antibiotic, used in the treatment, used in the treatment of gram-positive bacteria. Antibacterial;Bacterial transpeptidase inhibitor Nafcillin sodium salt monohydrate is an antibiotic resistant to beta-lactamase.
• Therapeutic Function: Antibacterial
• Clinical Use: Nafcillin sodium, 6-(2-ethoxy-1-naphthyl)penicillin sodium(Unipen), is another semisynthetic penicillin that resultedfrom the search for penicillinase-resistant compounds. Likemethicillin, nafcillin has substituents in positions ortho tothe point of attachment of the aromatic ring to the carboxamidegroup of penicillin. No doubt, the ethoxy group andthe second ring of the naphthalene group play steric roles instabilizing nafcillin against penicillinase. Very similar structureshave been reported to produce similar results in somesubstituted 2-biphenylpenicillins. Unlike methicillin, nafcillin is stable enough in acid topermit its use by oral administration. When it is givenorally, its absorption is somewhat slow and incomplete,but satisfactory plasma levels may be achieved in about1 hour. Relatively small amounts are excreted throughthe kidneys; most is excreted in the bile. Even thoughsome cyclic reabsorption from the gut may occur, nafcillingiven orally should be readministered every 4 to 6 hours.This salt is readily soluble in water and may be administeredintramuscularly or intravenously to obtain highplasma concentrations quickly for the treatment of seriousinfections.Nafcillin sodium may be used in infections causedsolely by penicillin G-resistant staphylococci or whenstreptococci are present also. Although it is recommendedthat it be used exclusively for such resistant infections, nafcillin is also effective against pneumococci and groupA -hemolytic streptococci. Because, like other penicillins,it may cause allergic side effects, it should be administeredwith care.