2-tert-butyl-4-methylphenyl diethyl phosphate

Base Information

• Chemical Name: 2-tert-butyl-4-methylphenyl diethyl phosphate
• CAS No.: 952665-30-4
• Molecular Formula: C₁₅H₂₅O₄P
• Molecular Weight: 300.335
• Mol file: 952665-30-4.mol

Synonyms:2-tert-butyl-4-methylphenyl diethyl phosphate

Chemical Property of 2-tert-butyl-4-methylphenyl diethyl phosphate

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-butyl-4-methylphenyl diethyl phosphate

There total 1 articles about 2-tert-butyl-4-methylphenyl diethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-tert-Butyl-4-methylphenol (2409-55-4) + diethyl chlorophosphate (814-49-3) → phosphoric acid 2-tert-butyl-4-methylphenyl ester diethyl ester (952665-30-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.75h;

Reference yield: 91.0%

phosphoric acid 2-tert-butyl-4-methylphenyl ester diethyl ester (952665-30-4) → m-t-butyltoluene (1075-38-3)

Guidance literature:

With ammonia; lithium; In diethyl ether; at -78 ℃; for 0.25h;

Reference yield:

phosphoric acid 2-tert-butyl-4-methylphenyl ester diethyl ester (952665-30-4) → (E)-2-(5-(tert-butyl)-2,4-dinitrophenyl)-N,N-dimethylethenamine (952665-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia / diethyl ether; water

2: sulfuric acid; nitric acid

3: 2,4-dichlorophenoxyacetic acid dimethylamine / N,N-dimethyl-formamide

With sulfuric acid; ammonia; nitric acid; 2,4-dichlorophenoxyacetic acid dimethylamine; In diethyl ether; water; N,N-dimethyl-formamide;

upstream raw materials:

2-tert-Butyl-4-methylphenol

diethyl chlorophosphate

Downstream raw materials:

m-t-butyltoluene

1-(tert-butyl)-3-methyl-2,4-dinitrobenzene

1-(tert-butyl)-5-methyl-2,4-dinitrobenzene

(E)-2-(5-(tert-butyl)-2,4-dinitrophenyl)-N,N-dimethylethenamine

Refernces

• 1、 Hadida, Sabine,Van Goor, Fredrick,Zhou, Jinglan,Arumugam, Vijayalaksmi,McCartney, Jason,Hazlewood, Anna,Decker, Caroline,Negulescu, Paul,Grootenhuis, Peter D. J.. "Discovery of N -(2,4-Di- tert -butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a potent and orally bioavailable CFTR potentiator". supporting information. p. 9776 - 9795. Retrieved 2015/01/16.
• 2、 -. "Modulators of ATP-binding cassette transporters". Page/Page column 149-150. . Retrieved 2008/06/13.