Clindamycin hydrochloride

Base Information

• Chemical Name: Clindamycin hydrochloride
• CAS No.: 21462-39-5
• Molecular Formula: C18H33ClN2O5S^.HCl
• Molecular Weight: 461.45
• Hs Code.: 29419000
• European Community (EC) Number: 244-398-6
• NSC Number: 756696
• NCI Thesaurus Code: C47977
• RXCUI: 81982
• ChEMBL ID: CHEMBL1452303
• Mol file: 21462-39-5.mol

Synonyms:7(S)-Chloro-7-deoxylincomycin hyddrochloride;L-threo-a-D-galacto-Octopyranoside, methyl7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,hydrochloride (1:1);7-Chloro-7-deoxylincomycin hydrochloride;Antirobe vet.;

Chemical Property of Clindamycin hydrochloride

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 1.79E-19mmHg at 25°C
• Melting Point: 141 °C
• Boiling Point: 647 °C at 760 mmHg
• Flash Point: 345.1 °C
• PSA: 127.56000
• Density: ==
• LogP: 1.52030
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL, clear, colorless
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 460.1565488
• Heavy Atom Count: 28
• Complexity: 502

Purity/Quality:

98%min ^*data from raw suppliers

Clindamycin Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl
• Isomeric SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H](C2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl.Cl
• Recent ClinicalTrials: Compound Adapalene and Clindamycin Hydrochloride Gel in Treatment of Patients With Acne
• Recent EU Clinical Trials: Dequalinium versus usual care antibiotics for the treatment of bacterial vaginosis (DEVA): a multicentre, randomised, open label, non-inferiority trial
• Uses: Clindamycin hydrochloride is a salt of clindamycin, a semi-synthetic lincosamide. The hydrochloride salt forms at the basic N-ethylproline moiety and is the preferred pharmaceutical formulation. Like other members of the lincosamide family, clindamycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin hydrochloride acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Clindamycin hydrochloride has been extensively studied with over 8,000 literature citations. Labelled Clindamycin. Semi-synthetic antibiotic prepared from Lincomycin;Labeled Clindamycin, intended for use as an internal standard for the quantification of Clindamycin by GC- or LC-mass spectrometry.
• Therapeutic Function: Antibacterial
• Clinical Use: Clindamycin is recommended for the treatment of a widevariety of upper respiratory, skin, and tissue infections causedby susceptible bacteria. Its activity against streptococci,staphylococci, and pneumococci is indisputably high, and it isone of the most potent agents available against somenon–spore-forming anaerobic bacteria, the Bacteroides spp.in particular. An increasing number of reports of clindamycin-associated GI toxicity, which range in severity fromdiarrhea to an occasionally serious pseudomembranous colitis,have, however, caused some clinical experts to call for areappraisal of the role of this antibiotic in therapy.Clindamycin- (or lincomycin)-associated colitis may be particularlydangerous in elderly or debilitated patients and hascaused deaths in such individuals. The colitis, which is usuallyreversible when the drug is discontinued, is now believedto result from an overgrowth of a clindamycin-resistant strainof the anaerobic intestinal bacterium Clostridium difficile.229The intestinal lining is damaged by a glycoprotein endotoxinreleased by lysis of this organism.The glycopeptide antibiotic vancomycin has been effectivein the treatment of clindamycin-induced pseudomembranouscolitis and in the control of the experimentally induced bacterial condition in animals. Clindamycin shouldbe reserved for staphylococcal tissue infections, such as cellulitisand osteomyelitis, in penicillin-allergic patients andfor severe anaerobic infections outside the central nervoussystem. Ordinarily, it should not be used to treat upper respiratorytract infections caused by bacteria sensitive to othersafer antibiotics or in prophylaxis.

Technology Process of Clindamycin hydrochloride

There total 2 articles about Clindamycin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

clindamycin (16684-06-3,18323-44-9,51064-35-8) → clindamycin hydrochloride (21462-39-5,17431-55-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 60 ℃; for 1h; pH=1; pH-value; Temperature; Large scale;

Reference yield:

→ clindamycin hydrochloride (21462-39-5,17431-55-9)

Guidance literature:

Reference yield:

clindamycin hydrochloride (21462-39-5,17431-55-9) → clindamycin phosphate (24729-96-2)

Guidance literature:

upstream raw materials:

clindamycin

Downstream raw materials:

clindamycin phosphate

C₃₃H₅₄N₄O₁₁S₃

C₂₁H₃₇ClN₂O₅S

Refernces

• 1、 -. "Crystaline clindamycin free base". . . Retrieved 2008/06/13.