Carbamic acid, [(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, 1,1-

Base Information

• Chemical Name: Carbamic acid, [(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, 1,1-
• CAS No.: 99216-67-8
• Molecular Formula: C9H19NO4
• Molecular Weight: 205.254
• Hs Code.: 2924199090
• Mol file: 99216-67-8.mol

Synonyms:Carbamic acid, [(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, 1,1-;N-BOC-L-THREONOL ;(1R,2R)-(2-Hydroxy-1-hydroxymethyl-propyl)-carbamic acid tert-butyl ester;tert-Butyl ((2R,3R)-1,3-dihydroxybutan-2-yl)carbamate

Chemical Property of Carbamic acid, [(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, 1,1-

Chemical Property:

• Vapor Pressure: 7.22E-07mmHg at 25°C
• Boiling Point: 366.8°C at 760 mmHg
• Flash Point: 175.6°C
• PSA: 78.79000
• Density: 1.108g/cm³
• LogP: 0.64370
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

tert-ButylN-[(2R,3R)-1,3-Dihydroxybutan-2-yl]carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, 1,1-

There total 9 articles about Carbamic acid, [(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, 1,1- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(tert-butoxycarbonyl)-l-threonine methyl ester (60538-19-4,79479-07-5,96099-84-2,113525-91-0) → 2-<<(tert-butoxy)carbonyl>amino>butane-1,3-diol (99216-67-8,766514-03-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2017.09.015

Reference yield: 87.0%

(2S,3R)-methyl 2-(tert-butoxycarbonyl)-3-hydroxybutanoate → 2-<<(tert-butoxy)carbonyl>amino>butane-1,3-diol (99216-67-8,766514-03-8)

Guidance literature:

(2S,3R)-methyl 2-(tert-butoxycarbonyl)-3-hydroxybutanoate; With sodium tetrahydroborate; In ethanol; at 0 - 23 ℃; for 3h;

With water; ammonium chloride; In ethanol; at 0 ℃;

Reference yield: 53.0%

1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate (98015-52-2) + L-threoninol (3228-51-1) → 2-<<(tert-butoxy)carbonyl>amino>butane-1,3-diol (99216-67-8,766514-03-8)

Guidance literature:

In 1,4-dioxane; tert-butyl alcohol; Ambient temperature;

DOI:10.1002/hlca.19890720620

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Boc-Thr-OH

1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate

L-threoninol

Downstream raw materials:

tert-butyl N-[(1S,2R)-2-hydroxy-1-(phenylsulfanylmethyl)propyl]carbamate

(2S,3S)-3-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester

[(1S,2R)-2,3-Bis-(diphenyl-phosphinoyl)-1-methyl-propyl]-carbamic acid tert-butyl ester

(2R,3S)-1,2-bis(diphenylphosphino)-3-tBoc-aminobutane

Refernces

• 1、 Cohen, Orit,Abu-Reziq, Raed,Gelman, Dmitri. "Chiral enantiopure organosilane precursors for the synthesis of periodic mesoporous organosilicas". . p. 1675 - 1685. Retrieved 2017/11/17.
• 2、 -. "IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS". Paragraph 0218-0220; 0231-0233. . Retrieved 2015/02/25.