N-[(3,4-DiMethoxy-2-pyridinyl)Methyl] Pantoprazole

Base Information

• Chemical Name: N-[(3,4-DiMethoxy-2-pyridinyl)Methyl] Pantoprazole
• CAS No.: 957470-59-6
• Molecular Formula: C₂₄H₂₄F₂N₄O₆S
• Molecular Weight: 534.541
• Mol file: 957470-59-6.mol

Synonyms:N-[(3,4-DiMethoxy-2-pyridinyl)Methyl] Pantoprazole;5-(DifluoroMethoxy)-1-[(3,4-diMethoxy-2-pyridinyl)Methyl]-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-1H-benziMidazole

Chemical Property of N-[(3,4-DiMethoxy-2-pyridinyl)Methyl] Pantoprazole

Chemical Property:

• Melting Point: 145-149 °C
• Boiling Point: 699.0±65.0 °C (760 mmHg)
• PSA: 126.03000
• Density: 1.43±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: 4.68390
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-[(3,4-Dimethoxy-2-pyridinyl)methyl]Pantoprazole(Mixtureof1and3isomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(3,4-DiMethoxy-2-pyridinyl)Methyl] Pantoprazole

There total 5 articles about N-[(3,4-DiMethoxy-2-pyridinyl)Methyl] Pantoprazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.33%

5-(difluoromethoxy)-1-[(3,4-dimethoxypyridin-2-yl)methyl]-2-{[(3,4-dimethoxypyridin-2-yl)methyl]thio}-1H-benzo[d]imidazole → 5-(difluoromethoxy)-1-[(3,4-dimethoxypyridin-2-yl)methyl]-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzo[d]imidazole (957470-59-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -10 ℃; for 1h;

Reference yield:

4-difluoromethoxy-2-nitroaniline (97963-76-3) → 5-(difluoromethoxy)-1-[(3,4-dimethoxypyridin-2-yl)methyl]-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzo[d]imidazole (957470-59-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: hydrazine hydrate; palladium on activated charcoal; methanol / 1 h / 75 °C

3.1: potassium hydroxide / ethanol / 2 h / 65 °C

4.1: sodium hydroxide / ethanol; water / 6 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -10 °C

With methanol; palladium on activated charcoal; sodium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride (72830-09-2) → 5-(difluoromethoxy)-1-[(3,4-dimethoxypyridin-2-yl)methyl]-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzo[d]imidazole (957470-59-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: hydrazine hydrate; palladium on activated charcoal; methanol / 1 h / 75 °C

3.1: potassium hydroxide / ethanol / 2 h / 65 °C

4.1: sodium hydroxide / ethanol; water / 6 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -10 °C

With methanol; palladium on activated charcoal; sodium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

4-difluoromethoxy-2-nitroaniline

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Refernces