5-Nitro-4-hydroxyquinazoline

Base Information

• Chemical Name: 5-Nitro-4-hydroxyquinazoline
• CAS No.: 99768-67-9
• Molecular Formula: C₈H₅N₃O₃
• Molecular Weight: 191.146
• Hs Code.: 2933990090
• Mol file: 99768-67-9.mol

Synonyms:5-Nitro-4-hydroxyquinazoline;5-Nitroquinazolin-4(3H)-one;5-Nitro-4(1H)-quinazolinone;5-Nitro-4(3H)-quinazolinone

Chemical Property of 5-Nitro-4-hydroxyquinazoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 148-152 °C
• Boiling Point: 414.463°C at 760 mmHg
• PKA: -0.50±0.20(Predicted)
• Flash Point: 204.46°C
• PSA: 91.83000
• Density: 1.589g/cm³
• LogP: 1.76680
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Nitro-4-hydroxyquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Nitro-4-hydroxyquinazoline

There total 2 articles about 5-Nitro-4-hydroxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formamide (77287-34-4,77287-35-5,60100-09-6) → 5-nitro-3H-quinazolin-4-one (99768-67-9)

Guidance literature:

at 150 - 160 ℃;

Reference yield:

6-nitroanthranilic acid (50573-74-5) + formamidine hydrochloride (6313-33-3) → 5-nitro-3H-quinazolin-4-one (99768-67-9)

Guidance literature:

at 200 ℃;

DOI:10.1016/j.bmcl.2010.04.070

Reference yield:

5-nitro-3H-quinazolin-4-one (99768-67-9) → quinazolin-5-ylamine (101421-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; PCl₅

2: palladium/CaCO₃; 2-methoxy-ethanol / Hydrogenation_.und anschliessend Dehydrierung mit Palladium/Kohle

With Lindlar's catalyst; 2-methoxy-ethanol; phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/ja01147a527

upstream raw materials:

formamide

6-nitroanthranilic acid

formamidine hydrochloride

Downstream raw materials:

5-amino-3H-quinazolin-4-one

quinazolin-5-ylamine

5-iodo-3H-quinazolin-4-one

Refernces