YH239-EE

Base Information

• Chemical Name: YH239-EE
• CAS No.: 1364488-67-4
• Molecular Formula: C₂₅H₂₇Cl₂N₃O₄
• Molecular Weight: 504.413
• Mol file: 1364488-67-4.mol

Synonyms:YH239-EE;Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate;YH239-EE ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate;Ethyl 3-[2-(tert-Butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoet;YH239-EE 6-Chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid Ethyl Ester;ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate

Chemical Property of YH239-EE

Chemical Property:

• Boiling Point: 763.3±60.0 °C(Predicted)
• PKA: 13.20±0.30(Predicted)
• PSA: 91.50000
• Density: 1.313±0.06 g/cm3(Predicted)
• LogP: 6.29260
• Solubility.: ≥50.4 mg/mL in DMSO; insoluble in H2O; ≥4.26 mg/mL in EtOH with ultrasonic

Purity/Quality:

98%min ^*data from raw suppliers

YH239-EE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

Technology Process of YH239-EE

There total 1 articles about YH239-EE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole- 2-carboxylate (1364488-67-4,1364489-39-3,1364489-40-6)

Guidance literature:

Reference yield:

ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole- 2-carboxylate (1364488-67-4,1364489-39-3,1364489-40-6) → ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indoIe-2-carboxylate + ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indoIe-2-carboxylate

Guidance literature:

With RegisCell (#784106, OD); In ethanol; carbon dioxide; at 40 ℃; Purification / work up; Resolution of racemate;

Refernces