3-O-TERT-BUTYLDIMETHYLSILYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE

Base Information

• Chemical Name: 3-O-TERT-BUTYLDIMETHYLSILYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE
• CAS No.: 168411-99-2
• Molecular Formula: C29H63N2O5PSi
• Molecular Weight: 578.88
• Mol file: 168411-99-2.mol

Synonyms:3-O-TERT-BUTYLDIMETHYLSILYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE

Chemical Property of 3-O-TERT-BUTYLDIMETHYLSILYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE

Chemical Property:

• Solubility.: Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

3-O-tert-Butyldimethylsilyl-D-Erythro-sphingosylphosphorylcholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-TERT-BUTYLDIMETHYLSILYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE

There total 2 articles about 3-O-TERT-BUTYLDIMETHYLSILYL-D-ERYTHRO-SPHINGOSYLPHOSPHORYLCHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H71N2O7PSi (1357001-19-4) → <(2S,3R,4E)-2-amino-3-(tert-butyldimethylsilyloxy)-4-octadecene-1-yl><2-(trimethylammonio)ethyl> phosphate (168411-99-2)

Guidance literature:

C₃₄H₇₁N₂O₇PSi; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2011.11.001

Reference yield:

Toluene-4-sulfonate{2-[[(E)-(2S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-octadec-4-enyloxy]-(2-cyano-ethoxy)-phosphoryloxy]-ethyl}-trimethyl-ammonium; → <(2S,3R,4E)-2-amino-3-(tert-butyldimethylsilyloxy)-4-octadecene-1-yl><2-(trimethylammonio)ethyl> phosphate (168411-99-2)

Guidance literature:

With dimethyl amine; In ethanol; for 10h; Yield given;

Reference yield:

<(2S,3R,4E)-2-amino-3-(tert-butyldimethylsilyloxy)-4-octadecene-1-yl><2-(trimethylammonio)ethyl> phosphate (168411-99-2) → sphingosylphosphorylcholine (1670-26-4,105615-55-2,82970-80-7)

Guidance literature:

With hydrogenchloride; In methanol; for 10h;

upstream raw materials:

C₃₄H₇₁N₂O₇PSi

Downstream raw materials:

sphingosylphosphorylcholine

Refernces

• 1、 Kratzer, Bernd,Schmidt, Richard R.. "Efficient Synthesis of Sphingosine-1-phosphate, Ceramide-1-phosphate, Lysosphingomyelin, and Sphingomyelin". . p. 957 - 964. Retrieved 2007/10/02.