5,6,7,8-Tetrahydro-1-naphthylamine

Base Information

• Chemical Name: 5,6,7,8-Tetrahydro-1-naphthylamine
• CAS No.: 2217-41-6
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Hs Code.: 29214990
• European Community (EC) Number: 218-713-2
• NSC Number: 53503
• UNII: U0L74S8K6G
• DSSTox Substance ID: DTXSID70176701
• Nikkaji Number: J42.466H
• Wikidata: Q72506275
• Mol file: 2217-41-6.mol

Synonyms:1-Naphthylamine,5,6,7,8-tetrahydro- (7CI,8CI);1,2,3,4-Tetrahydro-5-naphthalenamine;1,2,3,4-Tetrahydro-5-naphthylamine;1-Amino-5,6,7,8-tetrahydronaphthalene;5,6,7,8-Tetrahydro-1-naphthalenamine;5,6,7,8-Tetrahydro-1-naphthalenylamine;5-Amino-1,2,3,4-tetrahydronaphthalene;5-Aminotetralin;5-Tetralinylamine;NSC 53503;

Chemical Property of 5,6,7,8-Tetrahydro-1-naphthylamine

Chemical Property:

• Appearance/Colour: Clear yellow to brown liquid
• Vapor Pressure: 0.0032mmHg at 25°C
• Melting Point: 38 °C(lit.)
• Refractive Index: n20/D 1.590(lit.)
• Boiling Point: 283.2 °C at 760 mmHg
• PKA: 4.56±0.20(Predicted)
• Flash Point: 136.4 °C
• PSA: 26.02000
• Density: 1,062 g/cm³
• LogP: 2.72880
• Solubility.: miscible with Alcohol
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 147.104799419
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

98% ^*data from raw suppliers

5,6,7,8-Tetrahydro-1-naphthylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCC2=C(C1)C=CC=C2N
• Uses: 5,6,7,8-Tetrahydro-1-naphthylamine is used as a reagent in the synthesis of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. 5,6,7,8-Tetrahydro-1-naphthylamine is also used as a reagent in the synthesis of benzopyrans and related compounds as inhibitors of the hypoxia inducible factor pathway.

Technology Process of 5,6,7,8-Tetrahydro-1-naphthylamine

There total 27 articles about 5,6,7,8-Tetrahydro-1-naphthylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

naphthalene-1,8-diamine (479-27-6) → 1-amino-5,6,7,8-tetrahydronaphthalene (2217-41-6)

Guidance literature:

With hydrogen; In methanol; at 150 ℃; for 4h; under 16501.7 Torr; Solvent; Temperature; Pressure; Autoclave;

Reference yield: 97.4%

1,8-dinitronaphthalene (602-38-0) → 1-amino-5,6,7,8-tetrahydronaphthalene (2217-41-6)

Guidance literature:

With hydrogen; In methanol; at 150 ℃; for 6h; under 15001.5 Torr; Temperature; Solvent; Pressure; Autoclave;

Reference yield: 94.6%

1-amino-naphthalene (134-32-7) → 1-amino-5,6,7,8-tetrahydronaphthalene (2217-41-6)

Guidance literature:

With hydrogen; In ethanol; at 25 - 30 ℃;

upstream raw materials:

tetralin

1-Nitronaphthalene

6-nitrotetralin

5-nitro-1,2,3,4-tetrahydronaphthalene

Downstream raw materials:

N-(5,6,7,8-tetrahydro-[1]naphthyl)-phthalamic acid

N-[1-(5,6,7,8-tetrahydronaphthyl)]-3,4,5-trimethoxybenzylamine

N-[1-(5,6,7,8-tetrahydronaphthyl)]-3,4,5-trimethoxybenzamide

N-[1-(5,6,7,8-tetrahydronaphthyl)]-3,4-dimethoxybenzamide

Refernces

• 1、 Gal'bershtam,M.A. et al.. "-". . . Retrieved 1977.
• 2、 See, Yi Yang,Sanford, Melanie S.. "C-H Amination of Arenes with Hydroxylamine". supporting information. p. 2931 - 2934. Retrieved 2020/04/09.
• 3、 He, Yuan,Tang, Jinghua,Luo, Meiming,Zeng, Xiaoming. "Regioselective and Chemoselective Reduction of Naphthols Using Hydrosilane in Methanol: Synthesis of the 5,6,7,8-Tetrahydronaphthol Core". supporting information. p. 4159 - 4163. Retrieved 2018/07/29.