Technology Process of 2,6-Dimethyloctanoic acid methyl ester
There total 5 articles about 2,6-Dimethyloctanoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 6-methyloctanoate;
With
n-butyllithium; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
methyl iodide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 2h;
DOI:10.3762/bjoc.7.200
- Guidance literature:
-
trimethyl 2-phosphonopropionate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 40 ℃;
4-methylhexanal;
In
tetrahydrofuran; mineral oil;
for 24h;
Reflux;
With
platinum(IV) oxide; hydrogen;
In
methanol;
DOI:10.1002/cbdv.201000190
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride
2.1: pyridinium chlorochromate
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 40 °C
3.2: 24 h / Reflux
With
lithium aluminium tetrahydride; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; mineral oil;
3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1002/cbdv.201000190
