Sodium cyanate

Base Information

• Chemical Name: Sodium cyanate
• CAS No.: 917-61-3
• Molecular Formula: NaOCN
• Molecular Weight: 65.0069
• Hs Code.: 28380000
• Mol file: 917-61-3.mol

Synonyms:Cyanicacid, sodium salt (8CI,9CI);Sodium cyanate (6CI,7CI);Sodium cyanate (NaOCN);Sodium isocyanate;Zassol;

Chemical Property of Sodium cyanate

Chemical Property:

• Appearance/Colour: white powder or crystals
• Vapor Pressure: 6750mmHg at 25°C
• Melting Point: 550 °C
• Boiling Point: 23.5 °C at 760 mmHg
• PSA: 46.85000
• Density: 1.937 g/cm³
• LogP: -0.10202
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Water (Slightly)
• Water Solubility.: 110 g/L (20 ºC)

Purity/Quality:

97%, ^*data from raw suppliers

Sodium Cyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-52/53
• Safety Statements: 24/25-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Sodium cyanate belongs to the sodium salt of cyanic acid, which is commonly applied in the fields of chemical industry and medicine. Its industrial application is to serve as an intermediate in the production of dye-stuffs, bulk drug, heat treatment salts for metals, fungicides, herbicides, and photographic initiators. It is also an ideal nucleophile. The nucleophile properties of sodium cyanate makes it a major contributor to the stereospecificity in certain reactions such as in the production of chiral oxazolidone. Besides, it also acts as a reagent in the production of asymmetrical urea which have a range of biological activity mostly in aryl isocyanate intermediates. These intermediates and sodium cyanate have been applied in medicine, displaying counterbalancing carcinogenic effects on human body, which is probably effective with sickle cell anemia and helpful to block certain receptors for melanin which has been indicated to be helpful with obesity.
• Uses: Organic synthesis, heat treating of steel, inter- mediate for manufacture of medicinals. Sodium Cyanate is used in biological study as tumor cell proliferation and metabolism inhibition.

Technology Process of Sodium cyanate

There total 90 articles about Sodium cyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

[NaNV(N(3,5-Me2C6H3)(t-Bu))3]2 complex + carbon monoxide (201230-82-2) → V(N(3,5-Me2C6H3)(t-Bu))3 + sodium isocyanate (917-61-3)

Guidance literature:

In tetrahydrofuran; 1 atm of CO, THF, 23°C, 24 h; extd. with hexane, filtered, concd., the filtrate was stored at -35°C;

DOI:10.1021/ja807767w

Reference yield:

sodium carbamate (4296-19-9) → sodium isocyanate (917-61-3) + urea (57-13-6)

Guidance literature:

heating in NH3 from 60 until 200°C;

Reference yield:

sodium cyanide (773837-37-9) → sodium isocyanate (917-61-3) + sodium carbonate (497-19-8)

Guidance literature:

With air; In solid; at temp. 390 - 570 ° C in static air atm. at heating rate 5 °/min (TG/DSC expt.);; detected by IR;;

DOI:10.1007/BF01913779

upstream raw materials:

carbamic acid-(3-chloro-propyl ester)

sodium ethanolate

sodium cyanide

sodium butanolate

Downstream raw materials:

isocyanuric acid

2-Aethyl-2-chlormethyl-3-carbamoyloxy-propanol-1

4-phenyl-1,4-dihydro-benzo[d][1,2]oxazine-3-carboxylic acid amide

1-phenyl-1,4-dihydro-benzo[d][1,2]oxazine-3-carboxylic acid amide

Refernces

• 1、 Waddington. "". . p. 2499,2500. Retrieved 1959.
• 2、 Silvia, Jared S.,Cummins, Christopher C.. "Two-electron reduction of a vanadium(V) nitride by CO to release cyanate and open a coordination site". . p. 446 - 447. Retrieved 2009/06/23.
• 3、 Karachinskii, S. V.,Gazizov, R. R.,Dragalov, V. V.,Chimishkyan, A. L.. "REACTION OF UREA WITH ALKALI-METAL CARBONATES. II. EFFECT OF REACTION CONDITIONS ON SELECTIVITY OF THE PROCESS". . p. 1265 - 1268. Retrieved 2007/10/02.