3-AMINO CROTONIC ACID CINNAMYL ESTER

Base Information

• Chemical Name: 3-AMINO CROTONIC ACID CINNAMYL ESTER
• CAS No.: 103909-86-0
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.26
• Mol file: 103909-86-0.mol

Synonyms:3-AMINO CROTONIC ACID CINNAMYL ESTER;CINNAMYL 3-AMINOCROTONATE

Chemical Property of 3-AMINO CROTONIC ACID CINNAMYL ESTER

Chemical Property:

• Boiling Point: 386.3±30.0 °C(Predicted)
• PKA: 5.26±0.70(Predicted)
• PSA: 52.32000
• Density: 1.102±0.06 g/cm3(Predicted)
• LogP: 2.80580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(E)-Cinnamyl3-Aminobut-2-enoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-AMINO CROTONIC ACID CINNAMYL ESTER

There total 5 articles about 3-AMINO CROTONIC ACID CINNAMYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-3-phenyl-2-propen-1-ol (4407-36-7) → (E)-3-phenyl-2-propene-1-yl 3-aminocrotonate (103909-86-0,113898-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / toluene

2: AcONH₄ / propan-2-ol

With ammonium acetate; triethylamine; In isopropyl alcohol; toluene;

DOI:10.1016/j.bmcl.2005.11.021

Reference yield:

(E)-(3-phenylallyl) 3-oxo-butyrate (61363-91-5) → 3-amino-2-butenoic acid cinnamyl ester (103909-86-0,113898-97-8)

Guidance literature:

With ammonium carbonate; In ethanol; at 20 - 30 ℃; for 12h;

Reference yield:

cinnamyl 3-oxobutanoate (57582-46-4) → 3-amino-2-butenoic acid cinnamyl ester (103909-86-0,113898-97-8)

Guidance literature:

In ethanol; at 5 ℃; for 12h; Temperature;

upstream raw materials:

(E)-(3-phenylallyl) 3-oxo-butyrate

(2E)-3-phenyl-2-propen-1-ol

cinnamyl 3-oxobutanoate

Downstream raw materials:

cilnidipine

Refernces

• 1、 -. "Preparation method of 3-amino-2-butenoic acid cinnamyl ester". Paragraph 0035; 0040-0042; 0047-0049; 0054-0055; 0063. . Retrieved 2020/12/30.
• 2、 Yamamoto, Takashi,Niwa, Seiji,Ohno, Seiji,Onishi, Tomoyuki,Matsueda, Hiroyuki,Koganei, Hajime,Uneyama, Hisayuki,Fujita, Shin-Ichi,Takeda, Tomoko,Kito, Morikazu,Ono, Yukitsugu,Saitou, Yuki,Takahara, Akira,Iwata, Seinosuke,Shoji, Masataka. "Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels". . p. 798 - 802. Retrieved 2007/10/03.