Mirtazapine BroMide

Base Information

• Chemical Name: Mirtazapine BroMide
• CAS No.: 61337-86-8
• Molecular Formula: C₁₇H₁₈BrN₃
• Molecular Weight: 344.254
• Mol file: 61337-86-8.mol

Synonyms:Mirtazapine BroMide;8-BroMo Mirtazapine;8-BroMo-1,2,3,4,10,14b-hexahydro-2-Methyl-

Chemical Property of Mirtazapine BroMide

Chemical Property:

• PSA: 19.37000
• LogP: 3.24430
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

MirtazapineBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Mirtazapine Bromide (cas# 61337-86-8) is a compound useful in organic synthesis.

Technology Process of Mirtazapine BroMide

There total 3 articles about Mirtazapine BroMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Mirtazapine (85650-52-8,61337-67-5,61364-37-2) → 1,2,3,4,10,14b-hexahydro-8-bromo-2-methyl-pyrazino<2,1-a>pyrido<2,3-c><2>benzazepine (61337-86-8)

Guidance literature:

With bromine; In acetic acid; for 4h; Ambient temperature;

DOI:10.1002/recl.19851041004

Reference yield: 61.0%

C24H39N3O2Si3 → 1,2,3,4,10,14b-hexahydro-8-bromo-2-methyl-pyrazino<2,1-a>pyrido<2,3-c><2>benzazepine (61337-86-8)

Guidance literature:

With N-Bromosuccinimide; silver fluoride; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere; Glovebox;

DOI:10.1021/ja511352u

Reference yield:

→ 1,2,3,4,10,14b-hexahydro-8-bromo-2-methyl-pyrazino<2,1-a>pyrido<2,3-c><2>benzazepine (61337-86-8)

Guidance literature:

8-Unsubst. Verb., Br2/AcOH;

upstream raw materials:

Mirtazapine

Downstream raw materials:

1,2,3,4,10,14b-hexahydro-2-methylpyrazino<2,1-a>pyrido<2,3-c><2>benzazepin-8-ol

Refernces

• 1、 -. "INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES". . . Retrieved 2015/03/28.
• 2、 -. "Tetracyclic compounds". . . Retrieved 2008/06/13.