JWH 387

Base Information

• Chemical Name: JWH 387
• CAS No.: 1366067-59-5
• Molecular Formula: C24H22BrNO
• Molecular Weight: 420.34158
• Mol file: 1366067-59-5.mol

Synonyms:JWH 387;(4-broMonaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)Methanone

Chemical Property of JWH 387

Chemical Property:

• PSA: 22.00000
• LogP: 6.97820

Purity/Quality:

99% ^*data from raw suppliers

JWH 387 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: JWH 387 is an analgesic cannabimimetic derivative from the naphthoylindole family that acts a potent cannabinoid agonist at both CB1 and CB2 receptors.

Technology Process of JWH 387

There total 8 articles about JWH 387 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-pentyl-1H-indole (59529-21-4) + 4-bromo-1-naphthoic acid chloride (87700-65-0) → (4-bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (1366067-59-5)

Guidance literature:

1-pentyl-1H-indole; With dimethylaluminum chloride; In hexane; dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

4-bromo-1-naphthoic acid chloride; In hexane; dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2012.01.038

Reference yield: 18.0%

1-Bromopentane (110-53-2) + 3-(4-bromo-1-naphthoyl)indole (1366068-34-9) → (4-bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (1366067-59-5)

Guidance literature:

3-(4-bromo-1-naphthoyl)indole; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h;

1-Bromopentane; In dimethyl sulfoxide; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2012.01.038

Reference yield:

C17H13BrNO(1+)*I(1-) → (4-bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (1366067-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / 2 h / Reflux

2.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

3.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With thionyl chloride; water; dimethylaluminum chloride; sodium hydroxide; In hexane; dichloromethane; 3.1: Friedel-Crafts reaction / 3.2: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2012.01.038

upstream raw materials:

1-pentyl-1H-indole

4-bromo-1-naphthoic acid chloride

1-Bromopentane

3-(4-bromo-1-naphthoyl)indole

Refernces