IMidazo[1,2-a]pyridine-7-...

Base Information

• Chemical Name: IMidazo[1,2-a]pyridine-7-...
• CAS No.: 952566-04-0
• Molecular Formula: C₈H₅N₃
• Molecular Weight: 143.148
• Hs Code.: 2933990090
• Mol file: 952566-04-0.mol

Synonyms:Imidazo[1,2-a]pyridine-7-carbonitrile

Chemical Property of IMidazo[1,2-a]pyridine-7-...

Chemical Property:

• PSA: 41.09000
• LogP: 1.20598

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazo[1,2-a]pyridine-7-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IMidazo[1,2-a]pyridine-7-...

There total 2 articles about IMidazo[1,2-a]pyridine-7-... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

zinc(II) cyanide (557-21-1) + 7-chloroimidazo-[1,2-a]pyridine (4532-25-6) → imidazo[1,2-a]pyridine-7-carbonitrile (952566-04-0)

Guidance literature:

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; zinc; In acetonitrile; at 80 ℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.7b00732

Reference yield:

2-chloroethanal (107-20-0) + 4-cyanopyridin-2-amine (42182-27-4) → imidazo[1,2-a]pyridine-7-carbonitrile (952566-04-0)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; at 20 - 80 ℃; for 18h;

upstream raw materials:

2-chloroethanal

4-cyanopyridin-2-amine

zinc(II) cyanide

7-chloroimidazo-[1,2-a]pyridine

Refernces

• 1、 -. "Preparation method of aromatic nitrile compound or heteroaromatic nitrile compound". Paragraph 0043; 0045; 0216-0218. . Retrieved 2018/11/03.
• 2、 -. "NEW COMPOUNDS". Page/Page column 122-123. . Retrieved 2008/12/06.