(2-BroMoethyl)diphenylsulfoniuM TrifluoroMethanesulfonate

Base Information

• Chemical Name: (2-BroMoethyl)diphenylsulfoniuM TrifluoroMethanesulfonate
• CAS No.: 247129-85-7
• Molecular Formula: C15H14BrF3O3S2
• Molecular Weight: 443.2990696
• Hs Code.: 2930909090
• Mol file: 247129-85-7.mol

Synonyms:(2-BroMoethyl)diphenylsulfoniuM TrifluoroMethanesulfonate;(2-Bromoethyl)diphenylsulfonium trifluoromethanesulfonate 97%

Chemical Property of (2-BroMoethyl)diphenylsulfoniuM TrifluoroMethanesulfonate

Chemical Property:

• Melting Point: 88.0 to 92.0 °C
• PSA: 90.88000
• LogP: 5.25000

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Bromoethyl)diphenylsulfoniumtriflate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for:Sulfinylation reactionsCyclization reactionsAnnulation reactions

Technology Process of (2-BroMoethyl)diphenylsulfoniuM TrifluoroMethanesulfonate

There total 1 articles about (2-BroMoethyl)diphenylsulfoniuM TrifluoroMethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

diphenyl sulfide (139-66-2) + 2-bromoethyl triflate (103935-47-3) → (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate (247129-85-7)

Guidance literature:

In toluene; at 100 ℃; Inert atmosphere;

DOI:10.1039/c8ob00293b

Reference yield: 91.0%

1-(2-nitrobenzenesulfonyl)amino-4-(tert-butoxycarbonyl)aminobutane (211512-15-1) + (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate (247129-85-7) → tert-butyl (4-((N-(2-bromoethyl)-2-nitrophenyl)sulfonamido)butyl)carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/d0ob01713b

Reference yield: 91.0%

tert-butyl (S)-(1-((2-nitrophenyl)sulfonamido)propan-2-yl)-carbamate + (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate (247129-85-7) → tert-butyl (S)-(1-((N-(2-bromoethyl)-2-nitrophenyl)sulfonamido)propan-2-yl)carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/d0ob01713b

upstream raw materials:

diphenyl sulfide

2-bromoethyl triflate

Downstream raw materials:

methyl (3S)-4-[(4-methylphenyl)sulfonyl]morpholine-3-carboxylate

(1S,2R,5R)-2-methyl-3-[(4-methylphenyl)sulfonyl]-6-oxa-3-azabicyclo[3.1.0]hexane

(1S,2R,5R)-1,2-dimethyl-3-[(4-methylphenyl)sulfonyl]-6-oxa-3-azabicyclo[3.1.0]hexane

1(S),2(S),5(R)-1a-ethyl-2-methyl-3-[(4-methylphenyl)sulfonyl]tetrahydro-1aH-oxireno[2,3-c]pyrrole

Refernces

• 1、 Ming, Xiao-Xia,Wu, Shuai,Tian, Ze-Yu,Song, Jia-Wei,Zhang, Cheng-Pan. "Pd/Cu-Catalyzed Vinylation of Terminal Alkynes with (2-Bromoethyl)diphenylsulfonium Triflate". supporting information. p. 6795 - 6800. Retrieved 2021/09/08.
• 2、 -. "Salts and crystals of EGFR (epidermal growth factor receptor) inhibitor and their preparation methods". Paragraph 0098; 0101; 0102. . Retrieved 2018/05/16.