2-(Morpholin-4-yl)-4-phenylquinazoline

Base Information

• Chemical Name: 2-(Morpholin-4-yl)-4-phenylquinazoline
• CAS No.: 63615-58-7
• Molecular Formula: C18H17N3O
• Molecular Weight: 291.352
• NSC Number: 132404
• DSSTox Substance ID: DTXSID50299740
• Nikkaji Number: J2.748.296A
• Wikidata: Q82042331
• Mol file: 63615-58-7.mol

Synonyms:2-(morpholin-4-yl)-4-phenylquinazoline;63615-58-7;4-(4-phenylquinazolin-2-yl)morpholine;NSC132404;2-(4-morpholinyl)-4-phenylquinazoline;CBMicro_034975;Cambridge id 5849373;Oprea1_683222;Oprea1_858330;F0257-0072;DTXSID50299740;AKOS001152700;CCG-279826;NSC-132404;NCGC00299418-01;BIM-0034931.P001;AB00099213-01;AB00099213-03;Z57380517

Chemical Property of 2-(Morpholin-4-yl)-4-phenylquinazoline

Chemical Property:

• Vapor Pressure: 5.34E-10mmHg at 25°C
• Boiling Point: 496.6°Cat760mmHg
• Flash Point: 254.1°C
• Density: 1.221g/cm³
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 291.137162174
• Heavy Atom Count: 22
• Complexity: 352

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=NC3=CC=CC=C3C(=N2)C4=CC=CC=C4

Technology Process of 2-(Morpholin-4-yl)-4-phenylquinazoline

There total 4 articles about 2-(Morpholin-4-yl)-4-phenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

morpholine (110-91-8,99108-56-2) + 2-chloro-4-phenylquinazoline (29874-83-7) → 4-phenyl-2-(morpholin-1-yl)quinazoline (63615-58-7)

Guidance literature:

In 1,2-dimethoxyethane; for 3h; Reflux;

DOI:10.1002/asia.202100534

Reference yield: 78.0%

N-cyanomorpholine (1530-89-8) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 4-phenyl-2-(morpholin-1-yl)quinazoline (63615-58-7)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 110 ℃; for 12h; Reagent/catalyst;

DOI:10.1016/j.tetlet.2017.02.033

Reference yield: 55.0%

o-bromobenzophenone (13047-06-8) + N-Carboxyamidinomorpholine hemisulfate (17238-55-0,88497-68-1) → 4-phenyl-2-(morpholin-1-yl)quinazoline (63615-58-7)

Guidance literature:

o-bromobenzophenone; N-Carboxyamidinomorpholine hemisulfate; With caesium carbonate; L-proline; In N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere;

With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 40h; Inert atmosphere;

DOI:10.1055/s-0029-1216871

upstream raw materials:

N-phenyl-1-morpholinecarbimidoyl chloride

benzonitrile

o-bromobenzophenone

N-Carboxyamidinomorpholine hemisulfate

Refernces

• 1、 Pandya, Amit N.,Villa, Eric M.,North, E. Jeffrey. "A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation". supporting information. p. 1276 - 1279. Retrieved 2017/03/10.