5-broMo-4-Methoxy-6-MethylpyriMidine

Base Information

• Chemical Name: 5-broMo-4-Methoxy-6-MethylpyriMidine
• CAS No.: 4319-87-3
• Molecular Formula: C6H7BrN2O
• Molecular Weight: 203.038
• Hs Code.: 2933599090
• Mol file: 4319-87-3.mol

Synonyms:5-broMo-4-Methoxy-6-MethylpyriMidine

Chemical Property of 5-broMo-4-Methoxy-6-MethylpyriMidine

Chemical Property:

• Melting Point: 79-80 °C
• Boiling Point: 266.6±35.0 °C(Predicted)
• PKA: 2.22±0.26(Predicted)
• PSA: 35.01000
• Density: 1.534±0.06 g/cm3(Predicted)
• LogP: 1.55610
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-4-methoxy-6-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-broMo-4-Methoxy-6-MethylpyriMidine

There total 2 articles about 5-broMo-4-Methoxy-6-MethylpyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methanol (67-56-1) + 5-bromo-4-chloro-6-methylpyrimidine (3438-55-9) → 5-bromo-4-methoxy-6-methylpyrimidine (4319-87-3)

Guidance literature:

With sodium methylate; at 20 ℃; for 3h; chemoselective reaction;

DOI:10.1055/s-0030-1259976

Reference yield: 79.0%

sodium methylate (124-41-4) + 5-bromo-4-chloro-6-methylpyrimidine (3438-55-9) → 5-bromo-4-methoxy-6-methylpyrimidine (4319-87-3)

Guidance literature:

In methanol; at 20 ℃; for 1h;

Reference yield: 80.0%

{2-[(diethylamino)carbonyl]-5-fluorophenyl}boronic acid (868993-06-0) + 5-bromo-4-methoxy-6-methylpyrimidine (4319-87-3) → N,N-diethyl-4-fluoro-2-(4-methoxy-6-methylpyrimidin-5-yl)benzamide (868993-25-3)

Guidance literature:

{2-[(diethylamino)carbonyl]-5-fluorophenyl}boronic acid; 5-bromo-4-methoxy-6-methylpyrimidine; With sodium carbonate; In water; toluene; for 0.166667h;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 160 ℃; for 0.166667h; Microwave;

upstream raw materials:

sodium methylate

5-bromo-4-chloro-6-methylpyrimidine

methanol

Downstream raw materials:

N,N-diethyl-4-fluoro-2-(4-methoxy-6-methylpyrimidin-5-yl)benzamide

4-[4-(4-methoxy-6-methylpyrimidin-5-yl)-3-methylphenoxy]furo[3,2-c]pyridine

Refernces

• 1、 -. "TETRACYCLIC INHIBITORS OF JANUS KINASES". Page/Page column 67-68. . Retrieved 2008/06/13.